Effects of walnuts on endothelial function in overweight adults with visceral obesity: a randomized, controlled, crossover trial
Katz DL, Davidhi A, Ma Y, Kavak Y, Bifulco L, Njike VY
Journal of the American College of Nutrition · 91 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2012-12-01 · J Am Coll Nutr · vol. 31 · número 6 · págs. 415–423
- Editorial
- Taylor & Francis
- Citado
- 120 citas · más que el 95% de estudios similares · 4.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 41 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Botany, Ecology, and Taxonomy Studies · Peanut Plant Research Studies
- Palabras clave
- Medicine, Overweight, Crossover study, Diabetes mellitus, Internal medicine, Type 2 diabetes, Blood pressure, Population, Waist, Metabolic syndrome, Insulin resistance, Obesity, Randomized controlled trial, Brachial artery, Endocrinology, Placebo
- MeSH
- brachial artery, endothelium, vascular, humans, juglans, nuts, cardiovascular diseases, insulin, blood glucose, dietary fats, cross-over studies, single-blind method, vasodilation, adult, aged, middle aged, female, male, adiposity, overweight, obesity, abdominal, metabolic syndrome
6 autores
- David L. Katz🇺🇸 · autor de correspondenciaYale Griffin Prevention Research Center
- Anna Davidhi🇺🇸Griffin Hospital
- Yingying Ma🇺🇸Griffin Hospital
- Yasemin Kavak🇺🇸Griffin Hospital
- Lauren Bifulco🇺🇸Griffin Hospital
- Valentine Yanchou Njike🇺🇸Griffin Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Metabolic syndrome is a precursor of diabetes and cardiovascular disease (CVD). Walnut ingestion has been shown to reduce CVD risk indices in diabetes. This randomized controlled crossover trial was performed to investigate the effects of daily walnut consumption on endothelial function and other biomarkers of cardiac risk in a population of overweight individuals with visceral adiposity.
Methods
Forty-six overweight adults (average age, 57.4 years; 28 women, 18 men) with elevated waist circumference and 1 or more additional signs of metabolic syndrome were randomly assigned to two 8-week sequences of walnut-enriched ad libitum diet and ad libitum diet without walnuts, which were separated by a 4-week washout period. The primary outcome measure was the change in flow-mediated vasodilation (FMD) of the brachial artery. Secondary measures included serum lipid panel, fasting glucose and insulin, Homeostasis Model Assessment-Insulin Resistance values, blood pressure, and anthropometric measures.
Results
FMD improved significantly from baseline when subjects consumed a walnut-enriched diet as compared with the control diet (1.4% ± 2.4% versus 0.3% ± 1.5%; p = 0.019). Beneficial trends in systolic blood pressure reduction were seen, and maintenance of the baseline anthropometric values was also observed. Other measures were unaltered.
Conclusion
Daily ingestion of 56 g of walnuts improves endothelial function in overweight adults with visceral adiposity. The addition of walnuts to the diet does not lead to weight gain. Further study of the potential role of walnut intake in diabetes and CVD prevention is warranted.
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