Postdiagnosis cruciferous vegetable consumption and breast cancer outcomes: a report from the After Breast Cancer Pooling Project
Nechuta S, Caan BJ, Chen WY, Kwan ML, Lu W, Cai H, Poole EM, Flatt SW, Zheng W, Zheng W, Pierce JP, Shu XO
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 20 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Environmental Health Sciences
- Gobierno
- NIEHS NIH HHS
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Institute of Environmental Health Sciences (K12ES015855); National Cancer Institute (R01CA129059); National Cancer Institute (P01 CA087969); National Cancer Institute (T32CA009001); National Cancer Institute (R01 CA 118229); National Cancer Institute (3R01 CA118229-03S1); National Institute of Environmental Health Sciences (5K12ES015855); National Cancer Institute ([P01 CA87969)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-06-14 · Cancer Epidemiol Biomarkers Prev · vol. 22 · número 8 · págs. 1451–1456
- Editorial
- American Association for Cancer Research
- Citado
- 25 citas · más que el 75% de estudios similares · 1.0× el promedio de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Cancer Risks and Factors · Family Support in Illness
- Palabras clave
- Breast cancer, Medicine, Cruciferous vegetables, Pooling, Oncology, Cancer, Gynecology, Internal medicine, Environmental health
- MeSH
- humans, brassicaceae, vegetables, breast neoplasms, isothiocyanates, neoplasm staging, treatment outcome, diet, cohort studies, prospective studies, feeding behavior, middle aged, united states, china, female
11 autores
- Sarah Nechuta🇺🇸🇨🇳 · autor de correspondenciaBrigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Bette Jane Caan🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Wendy Y. Chen🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Marilyn L. Kwan🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Wei Lu🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Hui Cai🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Elizabeth M. Poole🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Shirley W. Flatt🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Wei Zheng🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- John P. Pierce🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
- Xiao Ou Shu🇺🇸🇨🇳Brigham and Women's Hospital; Kaiser Permanente; Harvard University; Dana-Farber Cancer Institute; Shanghai Municipal Center For Disease Control Prevention
Resumen
El texto original del estudio, en el idioma en que se publicó.
Cruciferous vegetables are a major source of glucosinolate-derived bioactive compounds such as isothiocyanates, which have been shown in animal and in vitro studies to inhibit cancer growth and progression. Few studies have investigated cruciferous vegetable intake after diagnosis and breast cancer outcomes. Using data from the After Breast Cancer Pooling Project, which includes prospective data from U.S. and Chinese breast cancer survivors, we evaluated the association of cruciferous vegetables with breast cancer outcomes. Analyses included 11,390 women diagnosed with stage I-III invasive breast cancer (1990-2006) from four cohorts. Cruciferous vegetable intake (g/day) was assessed using food frequency questionnaires (mean of 22 months postdiagnosis). Study heterogeneity was evaluated by the Q statistic; hazard ratios (HRs) and 95% confidence intervals (CI) were estimated using delayed-entry Cox regression models stratified by study. After a median follow-up of 9.0 years, 1,725 deaths and 1,421 recurrences were documented. In pooled analyses using study-specific quartiles, cruciferous vegetable intake was not associated with breast cancer outcomes, adjusting for known clinical prognostic factors and selected lifestyle factors. HRs (95% CIs) by increasing quartiles (reference = lowest quartile) were 1.08 (0.93-1.25), 1.01 (0.87-1.18), and 1.10 (0.95-1.28) for recurrence (P(trend) = 0.34) and 1.01 (0.88-1.15), 0.97 (0.84-1.11), and 0.99 (0.86-1.13) for total mortality (P(trend) = 0.84). No associations were observed for subgroups defined by estrogen receptor status, stage, or tamoxifen therapy. Cruciferous vegetable intake at approximately two years after diagnosis was not associated with recurrence or mortality. Our results do not support an association between postdiagnosis cruciferous vegetable intake and breast cancer outcomes.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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