Maternal vitamin D status and risk of pre-eclampsia: a systematic review and meta-analysis
Tabesh M, Salehi-Abargouei A, Tabesh M, Esmaillzadeh A
The Journal of clinical endocrinology and metabolism · 127 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-06-19 · J Clin Endocrinol Metab · vol. 98 · número 8 · págs. 3165–3173
- Editorial
- Oxford University Press
- Citado
- 199 citas · más que el 100% de estudios similares · 22.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- De pago
- Áreas de investigación
- Pregnancy and preeclampsia studies · Vitamin D Research Studies · Neurological Complications and Syndromes
- Palabras clave
- vitamin D deficiency, preeclampsia, maternal serum vitamin D, 25-hydroxyvitamin D, pregnancy complications, risk factors
- MeSH
- humans, pre-eclampsia, vitamin d, risk, pregnancy, female
4 autores
- Marjan Tabesh🇮🇷Isfahan University of Medical Sciences
- Amin Salehi‐Abargouei🇮🇷Isfahan University of Medical Sciences
- Maryam Tabesh🇮🇷Isfahan University of Medical Sciences
- Ahmad Esmaillzadeh🇮🇷 · autor de correspondenciaIsfahan University of Medical Sciences
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although several studies have investigated the association between maternal serum vitamin D levels and risk of pre-eclampsia, findings are inconsistent. This systematic review and meta-analysis of published observational studies was conducted to summarize the evidence on the association between maternal serum vitamin D levels and risk of pre-eclampsia.
Methods
PubMed, ISI (Web of science), SCOPUS, SCIRUS, Google Scholar, and EMBASE databases were searched to identify related articles published through December 2012. For systematic review, we found 15 articles that assessed the association between maternal serum vitamin D levels and risk of pre-eclampsia. The meta-analysis was done on 8 studies that reported odds ratios or relative risks for pre-eclampsia. Between-study heterogeneity was examined using Cochran's Q test and I(2). Subgroup analysis and meta-regression were used to find possible sources of heterogeneity.
Results
The meta-analysis on 8 relevant papers revealed an overall significant association between vitamin D deficiency and risk of pre-eclampsia; however, there was significant between-study heterogeneity (I(2) = 52.7%; P = .039). In the subgroup analysis, we found that the overall effect was significant for studies that defined vitamin D deficiency as 25(OH)D ≤ 50 nmol/L (20 ng/mL), but not for those that considered it as <38 nmol/L (15.2 ng/mL). The association was seen for "cohort or nested case-control studies" as well as for "cross-sectional or case-control studies" (2.78; 1.45-5.33; P = .002). When the analysis was done by study location, the associations remained significant only for studies that came from the United States.
Conclusion
There was a significant relationship between vitamin D deficiency and increased risk of pre-eclampsia. Further studies are required, particularly in developing countries.
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