Meta-analysis: vitamin D and non-alcoholic fatty liver disease
Eliades M, Spyrou E, Agrawal N, Lazo M, Brancati FL, Potter JJ, Koteish AA, Clark JM, Guallar E, Hernaez R
Alimentary pharmacology & therapeutics · 197 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-06-20 · Aliment Pharmacol Ther · vol. 38 · número 3 · págs. 246–254
- Editorial
- Wiley
- Citado
- 273 citas · más que el 99% de estudios similares · 13.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 59 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Vitamin D Research Studies · Liver Disease Diagnosis and Treatment · Hepatitis C virus research
- Palabras clave
- vitamin D, non-alcoholic fatty liver disease, 25-hydroxyvitamin D, vitamin D deficiency, serum vitamin D levels, NAFLD pathogenesis
- MeSH
- humans, fatty liver, vitamin d deficiency, vitamin d, case-control studies, cross-sectional studies, non-alcoholic fatty liver disease
10 autores
- Myrto Eliades🇺🇸 · autor de correspondenciaMedStar Washington Hospital Center
- Elias Spyrou🇺🇸MedStar Washington Hospital Center
- Neha Agrawal🇺🇸MedStar Washington Hospital Center
- Mariana Lazo🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- F. L. Brancati🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- James J. Potter🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Ayman A. Koteish🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Jeanne M. Clark🇺🇸Johns Hopkins University; Johns Hopkins Medicine
- Eliseo Güallar🇺🇸Johns Hopkins University
- Rubén Hernáez🇺🇸Johns Hopkins University; Johns Hopkins Medicine
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Non-alcoholic fatty liver disease (NAFLD) is a highly prevalent condition. Emerging evidence suggests that vitamin D may play a role in the pathogenesis of NAFLD.
Aim
To review systematically the association between vitamin D levels, measured as serum 25-hydroxy vitamin D [25(OH)D], and NAFLD.
Methods
We used PubMed and EMBASE databases to identify all studies that assessed the association between vitamin D and NAFLD up until 22 April 2013, without language restrictions. We included studies that compared vitamin D levels between NAFLD cases and controls and also those that compared the odds of vitamin D deficiency by NAFLD status. Pooled standardised differences and odds ratios were calculated using an inverse variance method.
Results
Seventeen cross-sectional and case-control studies have evaluated the association between vitamin D and NAFLD. NAFLD was diagnosed using biopsy (4 studies), ultrasound or CT (10 studies) and liver enzymes (3 studies). Nine studies provided data for a quantitative meta-analysis. Compared to controls, NAFLD patients had 0.36 ng/mL (95% CI: 0.32, 0.40 ng/mL) lower levels of 25(OH)D and were 1.26 times more likely to be vitamin D deficient (OR 1.26, 95% CI: 1.17, 1.35).
Conclusions
NAFLD patients have decreased serum 25(OH)D concentrations, suggesting that vitamin D may play a role in the development of NAFLD. The directionality of this association cannot be determined from cross-sectional studies. Demonstration of a causal role of hypovitaminosis D in NAFLD development in future studies could have important therapeutic implications.
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