Effects of creatine supplementation on oxidative stress and inflammatory markers after repeated-sprint exercise in humans
Deminice R, Rosa FT, Franco GS, Jordao AA, de Freitas EC
Nutrition (Burbank, Los Angeles County, Calif.) · 74 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Nível Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
- Gobierno
- Coordenação de Aperfeiçoamento de Pessoal de Ensino Superior
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-06-22 · Nutrition · vol. 29 · número 9 · págs. 1127–1132
- Editorial
- Elsevier BV
- Citado
- 133 citas · más que el 97% de estudios similares · 7.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 29 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Exercise and Physiological Responses · Muscle metabolism and nutrition · Sports Performance and Training
- Palabras clave
- creatine supplementation, oxidative stress, inflammation, repeated sprint exercise, TNF-α, C-reactive protein, malondialdehyde, lactate dehydrogenase, antioxidant enzymes, glutathione, youth athletes
- MeSH
- humans, inflammation, malondialdehyde, creatine, l-lactate dehydrogenase, superoxide dismutase, tumor necrosis factor-alpha, c-reactive protein, antioxidants, double-blind method, oxidative stress, running, soccer, dietary supplements, adolescent, male, sports nutritional physiological phenomena, biomarkers
5 autores
- Rafael Deminice🇧🇷 · autor de correspondenciaUniversidade Estadual de Londrina; Universidade de São Paulo
- Flávia Troncon Rosa🇧🇷Universidade de São Paulo
- Gabriel Silveira Franco🇧🇷Universidade de São Paulo
- Alceu Afonso Jordão🇧🇷Universidade de São Paulo
- Ellen Cristini de Freitas🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The goal of this study was to evaluate the effects of creatine (Cr) supplementation on oxidative stress and inflammation markers after acute repeated-sprint exercise in humans.
Methods
Twenty-five players under age 20 y were randomly assigned to two groups: Cr supplemented and placebo. Double-blind controlled supplementation was performed using Cr (0.3 g/kg) or placebo tablets for 7 d. Before and after 7 d of supplementation, the athletes performed two consecutive Running-based Anaerobic Sprint Tests (RAST). RAST consisted of six 35-m sprint runs at maximum speed with 10 sec rest between them. Blood samples were collected just prior to start of test (pre), just after the completion (0 h), and 1 h after completion.
Results
Average, maximum, and minimum power values were greater in the Cr-supplemented group compared with placebo (P < 0.05). There were significant increases (P < 0.05) in plasma tumor necrosis factor alpha (TNF-α) and C-reactive protein (CRP) up to 1 h after acute sprint exercise in the placebo-supplemented group. Malondialdehyde, lactate dehydrogenase (LDH), catalase, and superoxide dismutase enzymes also were increased after exercise in both groups. Red blood cell glutathione was lower after exercise in both groups. Cr supplementation reversed the increase in TNF-α and CRP as well as LDH induced by acute exercise. Controversially, Cr supplementation did not inhibit the rise in oxidative stress markers. Also, antioxidant enzyme activity was not different between placebo and Cr-supplemented groups.
Conclusion
Cr supplementation inhibited the increase of inflammation markers TNF-α and CRP, but not oxidative stress markers, due to acute exercise.
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