Antiplatelet effects of dietary nitrate in healthy volunteers: involvement of cGMP and influence of sex
Velmurugan S, Kapil V, Ghosh SM, Davies S, McKnight A, Aboud Z, Khambata RS, Webb AJ, Poole A, Ahluwalia A
Free radical biology & medicine · 98 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- British Heart Foundation
- Gobierno
- Medical Research Council
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- British Heart Foundation (FS/11/41/28749)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-06-25 · Free Radic Biol Med · vol. 65 · págs. 1521–1532
- Editorial
- Elsevier BV
- Citado
- 114 citas · más que el 98% de estudios similares · 7.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 62 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nitric Oxide and Endothelin Effects · Antiplatelet Therapy and Cardiovascular Diseases · Cardiovascular Syncope and Autonomic Disorders
- Palabras clave
- Nitrate, Ingestion, Platelet, Nitrite, Crossover study, Placebo, Epinephrine, Chemistry, Internal medicine, Platelet activation, Potassium nitrate, Endocrinology, Medicine, Potassium
- MeSH
- blood platelets, erythrocytes, humans, beta vulgaris, vegetables, cardiovascular diseases, nitrates, nitric oxide, potassium compounds, epinephrine, collagen, guanylate cyclase, p-selectin, cyclic gmp, platelet aggregation inhibitors, diet, cross-over studies, sex factors, platelet aggregation, dietary supplements, adolescent, adult, middle aged, female, male, young adult
10 autores
- Shanti Velmurugan🇬🇧Queen Mary University of London; William Harvey Research Institute
- Vikas Kapil🇬🇧Queen Mary University of London; William Harvey Research Institute
- Suborno M. Ghosh🇬🇧Queen Mary University of London; William Harvey Research Institute
- Sheridan Davies🇬🇧Queen Mary University of London; William Harvey Research Institute
- Andrew McKnight🇬🇧Queen Mary University of London; William Harvey Research Institute
- Zainab Aboud🇬🇧Queen Mary University of London; William Harvey Research Institute
- Rayomand S. Khambata🇬🇧Queen Mary University of London; William Harvey Research Institute
- David J. Webb🇬🇧Queen Mary University of London; William Harvey Research Institute
- Alastair W. Poole🇬🇧University of Bristol
- Amrita Ahluwalia🇬🇧 · autor de correspondenciaQueen Mary University of London; William Harvey Research Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Ingestion of vegetables rich in inorganic nitrate has emerged as an effective method, via the formation of a nitrite intermediate, for acutely elevating vascular NO levels. As such a number of beneficial effects of dietary nitrate ingestion have been demonstrated including the suggestion that platelet reactivity is reduced. In this study we investigated whether inorganic nitrate supplementation might also reduce platelet reactivity in healthy volunteers and have determined the mechanisms involved in the effects seen. We conducted two randomised crossover studies each in 24 (12 of each sex) healthy subjects assessing the acute effects of dietary nitrate (250 ml beetroot juice) or potassium nitrate capsules (KNO3, 8 mmol) vs placebo control on platelet reactivity. Inorganic nitrate ingested either from a dietary source or via supplementation raised circulating nitrate and nitrite levels in both sexes and attenuated ex vivo platelet aggregation responses to ADP and, albeit to a lesser extent, collagen but not epinephrine in male but not female volunteers. These inhibitory effects were associated with a reduced platelet P-selectin expression and elevated platelet cGMP levels. In addition, we show that nitrite reduction to NO occurs at the level of the erythrocyte and not the platelet. In summary, our results demonstrate that inorganic nitrate ingestion, whether via the diet or through supplementation, causes a modest decrease in platelet reactivity in healthy males but not females. Our studies provide strong support for further clinical trials investigating the potential of dietary nitrate as an adjunct to current antiplatelet therapies to prevent atherothrombotic complications. Moreover, our observations highlight a previously unknown sexual dimorphism in platelet reactivity to NO and intimate a greater dependence of males on the NO-soluble guanylate cyclase pathway in limiting thrombotic potential.
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