Prenatal vitamin d supplementation and child respiratory health: a randomised controlled trial
Goldring ST, Griffiths CJ, Martineau AR, Robinson S, Yu C, Poulton S, Kirkby JC, Stocks J, Hooper R, Shaheen SO, Warner JO, Boyle RJ
PloS one · 130 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute for Health and Care Research
- Organización sin fines de lucro
- Asthma and Lung UK
- Universidad u hospital
- Imperial College London
- Gobierno
- National Institute for Health Research (NIHR)
- Gobierno
- Medical Research Council
- Subvenciones
- National Institute for Health and Care Research (NF-SI-0509-10171)
Según 5 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-06-24 · PLoS One · vol. 8 · número 6 · pág. e66627
- Editorial
- Public Library of Science
- Citado
- 176 citas · más que el 99% de estudios similares · 13.1× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Asthma and respiratory diseases · Birth, Development, and Health
- Palabras clave
- prenatal vitamin D supplementation, childhood wheezing, vitamin D status, cord blood vitamin D, atopy, serum IgE, exhaled nitric oxide, lung function, respiratory infections, atopic dermatitis
- MeSH
- humans, respiratory tract infections, hypersensitivity, respiratory sounds, nitric oxide, vitamin d, immunoglobulin e, breath tests, prenatal care, pregnancy, dietary supplements, child, preschool, female, male
12 autores
- Stephen Goldring🇬🇧Imperial College London
- Chris J Griffiths🇬🇧Queen Mary University of London
- Adrian R. Martineau🇬🇧Queen Mary University of London
- Stephen Robinson🇬🇧Imperial College London
- Chang-Sik Yu🇬🇧Imperial College London
- Sheree Poulton🇬🇧Imperial College London
- Jane C. Kirkby🇬🇧University College London
- Janet Stocks🇬🇧University College London
- Richard Hooper🇬🇧Queen Mary University of London
- Seif O. Shaheen🇬🇧Queen Mary University of London
- John O. Warner🇬🇧Imperial College London
- Robert J. Boyle🇬🇧 · autor de correspondenciaImperial College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Observational studies suggest high prenatal vitamin D intake may be associated with reduced childhood wheezing. We examined the effect of prenatal vitamin D on childhood wheezing in an interventional study.
Methods
We randomised 180 pregnant women at 27 weeks gestation to either no vitamin D, 800 IU ergocalciferol daily until delivery or single oral bolus of 200,000 IU cholecalciferol, in an ethnically stratified, randomised controlled trial. Supplementation improved but did not optimise vitamin D status. Researchers blind to allocation assessed offspring at 3 years. Primary outcome was any history of wheeze assessed by validated questionnaire. Secondary outcomes included atopy, respiratory infection, impulse oscillometry and exhaled nitric oxide. Primary analyses used logistic and linear regression.
Results
We evaluated 158 of 180 (88%) offspring at age 3 years for the primary outcome. Atopy was assessed by skin test for 95 children (53%), serum IgE for 86 (48%), exhaled nitric oxide for 62 (34%) and impulse oscillometry of acceptable quality for 51 (28%). We found no difference between supplemented and control groups in risk of wheeze [no vitamin D: 14/50 (28%); any vitamin D: 26/108 (24%) (risk ratio 0.86; 95% confidence interval 0.49, 1.50; P = 0.69)]. There was no significant difference in atopy, eczema risk, lung function or exhaled nitric oxide between supplemented groups and controls.
Conclusion
Prenatal vitamin D supplementation in late pregnancy that had a modest effect on cord blood vitamin D level, was not associated with decreased wheezing in offspring at age three years.
Trial registration
Controlled-Trials.com ISRCTN68645785.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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