Financiado en parte por Oticon
A NO way to BOLD? Dietary nitrate alters the hemodynamic response to visual stimulation
Aamand R, Dalsgaard T, Ho YC, Møller A, Roepstorff A, Lund TE
NeuroImage · 41 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Solo mecanismos
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiado por la industria
- Gobierno
- Ministério da Ciência, Tecnologia e Inovação
- Organización sin fines de lucro
- Augustinus Fonden
- Organización sin fines de lucro
- Torben og Alice Frimodts Fond
- Organización sin fines de lucro
- Frimodt-Heineke Fonden
- Gobierno
- Danish Agency for Science and Higher Education
- Organización sin fines de lucro
- Letterstedtska
- Gobierno
- Danish Agency for Science, Technology and Innovation
- Organización sin fines de lucro
- Christian og Otillia Brorsons Rejselegat for yngre videnskabsmænd og -kvinder
- Gobierno
- Danish Ministry of Science, Technology and Innovation's UNIK program (MINDLab)
- Empresa
- Oticon
Según 10 financiadores declarados.
Publicación
- Publicado
- 2013-07-02 · Neuroimage · vol. 83 · págs. 397–407
- Editorial
- Elsevier BV
- Citado
- 55 citas · más que el 91% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 47 trabajos
- Acceso
- De pago
- Áreas de investigación
- Advanced MRI Techniques and Applications · Nitric Oxide and Endothelin Effects · Optical Imaging and Spectroscopy Techniques
- Palabras clave
- dietary nitrate, nitrate-nitrite-NO pathway, neurovascular coupling, BOLD signal, visual cortex, hemodynamic response, cerebral blood flow, nitric oxide, sodium nitrate
- MeSH
- humans, nitrates, nitrites, nitric oxide, magnetic resonance imaging, blood flow velocity, brain mapping, administration, oral, sensitivity and specificity, cross-over studies, double-blind method, reproducibility of results, photic stimulation, visual perception, placebo effect, cerebrovascular circulation, adult, male
6 autores
- Rasmus Aamand🇩🇰 · autor de correspondenciaAarhus University
- Thomas Dalsgaard🇩🇰Aarhus University
- Yi-Ching Lynn Ho🇩🇰Aarhus University
- Arne Møller🇩🇰Aarhus University; Aarhus University Hospital
- Andreas Roepstorff🇩🇰Aarhus University
- Torben E. Lund🇩🇰Aarhus University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Neurovascular coupling links neuronal activity to vasodilation. Nitric oxide (NO) is a potent vasodilator, and in neurovascular coupling NO production from NO synthases plays an important role. However, another pathway for NO production also exists, namely the nitrate-nitrite-NO pathway. On this basis, we hypothesized that dietary nitrate (NO3-) could influence the brain's hemodynamic response to neuronal stimulation. In the present study, 20 healthy male participants were given either sodium nitrate (NaNO3) or sodium chloride (NaCl) (saline placebo) in a crossover study and were shown visual stimuli based on the retinotopic characteristics of the visual cortex. Our primary measure of the hemodynamic response was the blood oxygenation level dependent (BOLD) response measured with high-resolution functional magnetic resonance imaging (0.64×0.64×1.8 mm) in the visual cortex. From this response, we made a direct estimate of key parameters characterizing the shape of the BOLD response (i.e. lag and amplitude). During elevated nitrate intake, corresponding to the nitrate content of a large plate of salad, both the hemodynamic lag and the BOLD amplitude decreased significantly (7.0±2% and 7.9±4%, respectively), and the variation across activated voxels of both measures decreased (12.3±4% and 15.3±7%, respectively). The baseline cerebral blood flow was not affected by nitrate. Our experiments demonstrate, for the first time, that dietary nitrate may modulate the local cerebral hemodynamic response to stimuli. A faster and smaller BOLD response, with less variation across local cortex, is consistent with an enhanced hemodynamic coupling during elevated nitrate intake. These findings suggest that dietary patterns, via the nitrate-nitrite-NO pathway, may be a potential way to affect key properties of neurovascular coupling. This could have major clinical implications, which remain to be explored.
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