Vitamin D and Respiratory Tract Infections: A Systematic Review and Meta-Analysis of Randomized Controlled Trials
Bergman P, Lindh AU, Björkhem-Bergman L, Lindh JD
PloS one · 281 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Karolinska Institutet
- Gobierno
- Stockholms Läns Landsting
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-06-19 · PLoS One · vol. 8 · número 6 · pág. e65835
- Editorial
- Public Library of Science
- Citado
- 428 citas · más que el 96% de estudios similares · 4.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 45 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Respiratory viral infections research · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, respiratory infections, infection control, 25-hydroxyvitamin D, once-daily dosing, bolus dosing, publication bias, trial heterogeneity
- MeSH
- humans, respiratory tract infections, vitamin d, treatment outcome, odds ratio, prospective studies, dietary supplements, female, male, randomized controlled trials as topic
4 autores
- Peter Bergman🇸🇪Karolinska Institutet
- Åsa U. Lindh🇸🇪Saint Göran Hospital
- Linda Björkhem‐Bergman🇸🇪Karolinska Institutet
- Jonatan D. Lindh🇸🇪 · autor de correspondenciaKarolinska Institutet
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Low levels of 25-OH vitamin D are associated with respiratory tract infection (RTI). However, results from randomized controlled trials are inconclusive. Therefore, we performed a systematic review and meta-analysis to assess the preventive effect of vitamin D supplementation on RTI.
Methods
Randomized, controlled trials of vitamin D for prevention of RTI were used for the analysis. The risks of within-trial and publication bias were assessed. Odds ratios of RTI were pooled using a random-effects model. Heterogeneity was assessed using Cochran's Q and I(2). Meta-regressions and subgroup analyses were used to assess the influence of various factors on trial outcome. The pre-defined review protocol was registered at the PROSPERO international prospective register of systematic reviews, registration number CRD42013003530.
Findings
Of 1137 citations retrieved, 11 placebo-controlled studies of 5660 patients were included in the meta-analysis. Overall, vitamin D showed a protective effect against RTI (OR, 0.64; 95% CI, 0.49 to 0.84). There was significant heterogeneity among studies (Cohran's Q p<0.0001, I(2) = 72%). The protective effect was larger in studies using once-daily dosing compared to bolus doses (OR = 0.51 vs OR = 0.86, p = 0.01). There was some evidence that results may have been influenced by publication bias.
Interpretation
Results indicate that vitamin D has a protective effect against RTI, and dosing once-daily seems most effective. Due to heterogeneity of included studies and possible publication bias in the field, these results should be interpreted with caution.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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