Acute caffeine administration impact on working memory-related brain activation and functional connectivity in the elderly: a BOLD and perfusion MRI study
Haller S, Rodriguez C, Moser D, Toma S, Hofmeister J, Sinanaj I, Van De Ville D, Giannakopoulos P, Lovblad KO
Neuroscience · 37 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Gobierno
- Swiss National Science Foundation
- Subvenciones
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (3200B0); Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (124111); Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung (116193)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-07-19 · Neuroscience · vol. 250 · págs. 364–371
- Editorial
- Elsevier BV
- Citado
- 52 citas · más que el 92% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 54 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Coffee research and impacts · Functional Brain Connectivity Studies · Neural and Behavioral Psychology Studies
- Palabras clave
- caffeine, working memory, older adults, brain activation, functional connectivity, cerebral perfusion, arterial spin labeling, BOLD fMRI, adenosine receptors, striatum, prefrontal cortex, parietal cortex, cognitive enhancement
- MeSH
- brain, neural pathways, humans, oxygen, spin labels, caffeine, central nervous system stimulants, magnetic resonance imaging, linear models, cross-over studies, double-blind method, memory, short-term, psychomotor performance, cerebrovascular circulation, principal component analysis, image processing, computer-assisted, aged, aged, 80 and over, middle aged, female, male
9 autores
- Sven Haller🇨🇭 · autor de correspondenciaUniversity of Geneva; University Hospital of Geneva
- Cristelle K. Rodriguez🇨🇭University of Geneva; University Hospital of Geneva
- Dominik Andreas Moser🇨🇭University of Geneva; University Hospital of Geneva
- S. Toma🇨🇭University of Geneva; University Hospital of Geneva
- Jérémy Hofmeister🇨🇭University of Geneva; University Hospital of Geneva
- Indrit Sinanaj🇨🇭University of Geneva; University Hospital of Geneva
- Dimitri Van De Ville🇨🇭University of Geneva; École Polytechnique Fédérale de Lausanne
- Pantéleimon Giannakopoulos🇨🇭University of Geneva; University Hospital of Geneva
- Karl‐Olof Lövblad🇨🇭University of Geneva; University Hospital of Geneva
Resumen
El texto original del estudio, en el idioma en que se publicó.
In young individuals, caffeine-mediated blockade of adenosine receptors and vasoconstriction has direct repercussions on task-related activations, changes in functional connectivity, as well as global vascular effects. To date, no study has explored the effect of caffeine on brain activation patterns during highly demanding cognitive tasks in the elderly. This prospective, placebo-controlled crossover design comprises 24 healthy elderly individuals (mean age 68.8 ± 4.0 years, 17 females) performing a 2-back working memory (WM) task in functional magnetic resonance imaging (fMRI). Analyses include complimentary assessment of task-related activations (general linear model, GLM), functional connectivity (tensorial independent component analysis, TICA), and baseline perfusion (arterial spin labeling). Despite a reduction in whole-brain global perfusion (-22.7%), caffeine-enhanced task-related GLM activation in a local and distributed network is most pronounced in the bilateral striatum and to a lesser degree in the right middle and inferior frontal gyrus, bilateral insula, left superior and inferior parietal lobule as well as in the cerebellum bilaterally. TICA was significantly enhanced (+8.2%) in caffeine versus placebo in a distributed and task-relevant network including the pre-frontal cortex, the supplementary motor area, the ventral premotor cortex and the parietal cortex as well as the occipital cortex (visual stimuli) and basal ganglia. The inverse comparison of placebo versus caffeine had no significant difference. Activation strength of the task-relevant-network component correlated with response accuracy for caffeine yet not for placebo, indicating a selective cognitive effect of caffeine. The present findings suggest that acute caffeine intake enhances WM-related brain activation as well as functional connectivity of blood oxygen level-dependent fMRI in elderly individuals.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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