Combined fish oil and high oleic sunflower oil supplements neutralize their individual effects on the lipid profile of healthy men
Hlais S, El-Bistami D, El Rahi B, Mattar MA, Obeid OA
Lipids · 23 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-07-25 · Lipids · vol. 48 · número 9 · págs. 853–861
- Editorial
- Wiley
- Citado
- 38 citas · más que el 78% de estudios similares · 1.3× el promedio de su campo
- Referencias
- 36 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Diet, Metabolism, and Disease · Dietary Effects on Health
- Palabras clave
- Lipidology, Clinical chemistry, Sunflower oil, Fish oil, Fish <Actinopterygii>, Food science, Chemistry, Biology, Biochemistry, Fishery
- MeSH
- animals, humans, cholesterol, insulin, blood glucose, lipids, fatty acids, omega-3, triglycerides, fish oils, plant oils, body mass index, drug administration schedule, analysis of variance, single-blind method, blood pressure, time factors, dietary supplements, adolescent, adult, male, cholesterol, ldl, young adult, sunflower oil, glycated hemoglobin
5 autores
- Sani Hlais🇱🇧American University of Beirut
- Dunia El‐Bistami🇱🇧American University of Beirut
- Berna Rahi🇱🇧American University of Beirut
- Mohab Mattar🇱🇧American University of Beirut
- Omar Obeid🇱🇧 · autor de correspondenciaAmerican University of Beirut
Resumen
El texto original del estudio, en el idioma en que se publicó.
Both n-3 and n-9 fatty acids share a common metabolic pathway and can potentially and individually improve cardiovascular disease risk factors. Dietary n-6 is known to weaken the efficacy of n-3 fatty acids due to competition for the same enzymes. Still unclear is whether a similar competition exists between n-3 and n-9 fatty acids. Thus, a 12-week intervention study was conducted to investigate the effect of different combinations of fish oil and high-oleic sunflower oil (OSO) on healthy subjects. Included were five groups (98 subjects): three groups received a fixed amount of n-9 (8 g/day) with varying amounts of n-3 (1, 2 or 4 g/day), one group was given n-3 fatty acids only (2 g/day) and another was given n-9 only (8 g/day). We found that fish oil supplement (2 g/day) was able to decrease TAG by about 13 %, this effect was diminished with the co-ingestion of n-9 (OSO). Intake of OSO (8 g/day) reduced both total and LDL cholesterol by about 10 %, this effect was reduced by the addition of fish oil. Both fish oil and OSO failed to have any significant effect on both glycemic and blood pressure parameters. In conclusion; the impact of oleic acid (n-9) on total and LDL cholesterol was altered by the addition fish oil (n-3). These effects may have been the result of enzymatic competition between the two types of fatty acids.
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