Does vitamin D improve osteoarthritis of the knee: a randomized controlled pilot trial
Sanghi D, Mishra A, Sharma AC, Singh A, Natu SM, Agarwal S, Srivastava RN
Clinical orthopaedics and related research · 108 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-07-31 · Clin Orthop Relat Res · vol. 471 · número 11 · págs. 3556–3562
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 151 citas · más que el 97% de estudios similares · 6.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 27 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Osteoarthritis Treatment and Mechanisms · Musculoskeletal pain and rehabilitation
- Palabras clave
- vitamin D supplementation, knee osteoarthritis, vitamin D insufficiency, 25-hydroxyvitamin D, knee pain, knee function, serum calcium, alkaline phosphatase, biochemical markers
- MeSH
- knee joint, humans, arthralgia, osteoarthritis, knee, vitamin d deficiency, calcium, alkaline phosphatase, vitamin d, pain measurement, treatment outcome, chi-square distribution, prospective studies, pilot projects, double-blind method, recovery of function, time factors, dietary supplements, adult, aged, middle aged, india, female, male, biomechanical phenomena, biomarkers
7 autores
- Divya Sanghi🇮🇳King George's Medical University
- Abhishek Mishra🇮🇳King George's Medical University
- Amar Chandra Sharma🇮🇳King George's Medical University
- Ajai Kumar Singh🇮🇳King George's Medical University
- S. M. Natu🇮🇳King George's Medical University
- Sarita Agarwal🇮🇳Sanjay Gandhi Post Graduate Institute of Medical Sciences
- Rajeshwar Nath Srivastava🇮🇳King George's Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Animal, epidemiologic, and human clinical studies suggest a putative role for vitamin D in osteoarthritis (OA). Inadequate sunlight exposure and lower serum levels of 25(OH)D appear in some reports to be associated with an increased risk for progression of knee OA.
Questions/purposes
We asked whether treatment with vitamin D would (1) reduce knee pain (WOMAC and VAS), (2) improve function (WOMAC), and (3) change levels of relevant biochemical markers in patients with knee OA with vitamin D insufficiency.
Methods
This randomized controlled pilot trial prospectively enrolled 107 patients with knee OA with vitamin D insufficiency (25(OH)D ≤ 50 nmol/L) to receive oral vitamin D or placebo. The primary outcome measures were pain and function, and the secondary were biochemical markers. At baseline, the two groups were comparable. The patients were followed for 1 year.
Results
At 12 months, knee pain had decreased in the vitamin D group by mean -0.26 (95% CI, -2.82 to -1.43) on VAS and -0.55 (95% CI, -0.07 to 1.02) on the WOMAC, whereas in the placebo group, it increased by mean 0.13 (95% CI, -0.03 to 0.29) on the VAS and 1.16 (95% CI, 0.82 to 1.49) on the WOMAC (effect size = 0.37 and 0.78). Likewise knee function improved in the vitamin D group by mean -1.36 (95% CI, -1.87 to -0.85) over the placebo group which had a mean 0.69 (95% CI, -0.03 to 1.41; effect size = 0.06). There were significant biochemical changes in serum total calcium, 25(OH)D and alkaline phosphatase.
Conclusions
The results above suggest there is a small but statistically significant clinical benefit to vitamin D treatment in patients with knee OA, although we recommend a long-term study to determine whether these changes are clinically important and whether they will be sustained with time. Further studies with long-term radiologic evaluations are needed.
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