The serum 25-hydroxyvitamin D response to vitamin D supplementation is related to genetic factors, BMI, and baseline levels
Didriksen A, Grimnes G, Hutchinson MS, Kjærgaard M, Svartberg J, Joakimsen RM, Jorde R
European journal of endocrinology · 96 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Helse Nord RHF
- Organización sin fines de lucro
- Nasjonalforeningen for Folkehelsen
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-08-10 · Eur J Endocrinol · vol. 169 · número 5 · págs. 559–567
- Editorial
- Oxford University Press
- Citado
- 117 citas · más que el 98% de estudios similares · 7.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Nutrition, Genetics, and Disease · Pharmacogenetics and Drug Metabolism
- Palabras clave
- 25-hydroxyvitamin D, vitamin D supplementation, genetic polymorphism, vitamin D binding protein, CYP2R1, body mass index, vitamin D metabolism genes
- MeSH
- humans, insulin resistance, hydroxycholecalciferols, parathyroid hormone, vitamins, vitamin d, absorptiometry, photon, anthropometry, body mass index, postmenopause, bone density, genotype, polymorphism, single nucleotide, dietary supplements, adult, aged, aged, 80 and over, middle aged, female, male, genome-wide association study
7 autores
- Allan Didriksen🇳🇴 · autor de correspondenciaUiT The Arctic University of Norway
- Guri Grimnes🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Moira Strand Hutchinson🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Marie Kjærgaard🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Johan Bernhard Svartberg🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Ragnar Martin Joakimsen🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
- Rolf Jorde🇳🇴University Hospital of North Norway; UiT The Arctic University of Norway
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The serum 25-hydroxyvitamin D (25(OH)D) level is not only dependent on vitamin D intake and production in the skin but also dependent on genetic factors. Thus, in large genome-wide association studies, it has been shown that single nucleotide polymorphisms (SNPs) in the vitamin D binding protein (DBP), as well as in enzymes related to activation or degradation of vitamin D and its metabolites, are as important for the serum 25(OH)D level as the effect of season. How these SNPs affect the serum 25(OH)D response to vitamin D supplementation is uncertain.
Design and methods
Data were pooled from three randomized controlled trials where 40, 000 IU vitamin D/week was given for 6 months. Serum 25(OH)D was measured before and at the end of the intervention, and the subjects were genotyped for SNPs related to the serum 25(OH)D level.
Results
Baseline 25(OH)D levels were significantly related to SNPs in the DBP and CYP2R1 genes. Those with SNPs associated with the lowest baseline 25(OH)D levels also had the smallest increase (delta) after supplementation. Those with the lowest baseline serum 25(OH)D (without regard to genotypes) had the highest increase (delta) after supplementation. Subjects with high BMI had lowest baseline 25(OH)D levels and also the smallest increase (delta) after supplementation.
Conclusions
The serum 25(OH)D response to supplementation depends on genes, baseline level, and BMI. However, whether this is clinically important or not depends on the therapeutic window of vitamin D, an issue that is still not settled.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.