Effects of wheat and oat-based whole grain foods on serum lipoprotein size and distribution in overweight middle aged people: a randomised controlled trial
Tighe P, Duthie G, Brittenden J, Vaughan N, Mutch W, Simpson WG, Duthie S, Horgan GW, Thies F
PloS one · 12 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
Según la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-08-05 · PLoS One · vol. 8 · número 8 · pág. e70436
- Editorial
- Public Library of Science
- Citado
- 16 citas · más que el 71% de estudios similares · 0.7× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Seed and Plant Biochemistry
- Palabras clave
- Medicine, Overweight, Lipoprotein, Lipoprotein(a), Avena, Refined grains, Obesity, Whole grains, Blood lipids, Internal medicine, Physiology, Animal science, Food science, Cholesterol, Biology, Agronomy
- MeSH
- humans, triticum, lipoproteins, adult, aged, middle aged, female, male, overweight, avena
9 autores
- Paula Tighe🇬🇧University of Aberdeen
- Garry G. Duthie🇬🇧University of Aberdeen
- Julie Brittenden🇬🇧University of Aberdeen
- Nicholas J. Vaughan🇬🇧University of Aberdeen
- William James Mutch🇬🇧National Health Service; NHS Grampian
- William G. Simpson🇬🇧National Health Service; NHS Grampian
- Susan J. Duthie🇬🇧University of Aberdeen
- Graham William Horgan🇬🇧Biomathematics and Statistics Scotland
- Frank Thiès🇬🇧 · autor de correspondenciaUniversity of Aberdeen
Resumen
El texto original del estudio, en el idioma en que se publicó.
Introduction
Epidemiological studies suggest three daily servings of whole-grain foods (WGF) might lower cardiovascular disease risk, at least partly by lowering serum lipid levels. We have assessed the effects of consuming three daily portions of wholegrain food (provided as wheat or a mixture of wheat and oats) on lipoprotein subclass size and concentration in a dietary randomised controlled trial involving middle aged healthy individuals.
Methods
After a 4-week run-in period on a refined diet, volunteers were randomly allocated to a control (refined diet), wheat, or wheat + oats group for 12 weeks. Our servings were determined in order to significantly increase the intakes of non starch polysaccharides to the UK Dietary Reference Value of 18 g per day in the whole grain groups (18.5 g and 16.8 g per day in the wheat and wheat + oats groups respectively in comparison with 11.3 g per day in the control group). Outcome measures were serum lipoprotein subclasses' size and concentration. Habitual dietary intake was assessed prior and during the intervention. Of the 233 volunteers recruited, 24 withdrew and 3 were excluded.
Results
At baseline, significant associations were found between lipoprotein size and subclasses' concentrations and some markers of cardiovascular risk such as insulin resistance, blood pressure and serum Inter cellular adhesion molecule 1 concentration. Furthermore, alcohol and vitamin C intake were positively associated with an anti-atherogenic lipoprotein profile, with regards to lipoprotein size and subclasses' distribution. However, none of the interventions with whole grain affected lipoprotein size and profile.
Conclusion
Our results indicate that three portions of wholegrain foods, irrelevant of the type (wheat or oat-based) do not reduce cardiovascular risk by beneficially altering the size and distribution of lipoprotein subclasses.
Trial registration
www.Controlled-Trials.com ISRCTN 27657880.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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