Long-term effect of high dose omega-3 fatty acid supplementation for secondary prevention of cardiovascular outcomes: A meta-analysis of randomized, placebo controlled trials [corrected]
Casula M, Soranna D, Catapano AL, Corrao G
Atherosclerosis. Supplements · 99 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-08-01 · Atheroscler Suppl · vol. 14 · número 2 · págs. 243–251
- Editorial
- Elsevier BV
- Citado
- 152 citas · más que el 89% de estudios similares · 2.5× el promedio de su campo
- Referencias
- 58 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Nutritional Studies and Diet · Cardiac Health and Mental Health
- Palabras clave
- omega-3 fatty acids, high-dose supplementation, secondary prevention, cardiovascular disease, cardiovascular mortality, sudden death, myocardial infarction, stroke, all-cause mortality
- MeSH
- humans, cardiovascular diseases, disease progression, fatty acids, omega-3, treatment outcome, odds ratio, risk factors, double-blind method, randomized controlled trials as topic, secondary prevention
4 autores
- Manuela Casula🇮🇹 · autor de correspondenciaUniversity of Milan
- Davide Soranna🇮🇹University of Milano-Bicocca
- Alberico Luigi Catapano🇮🇹University of Milan; MultiMedica
- Giovanni Corrao🇮🇹 · autor de correspondenciaUniversity of Milano-Bicocca
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Although omega-3 fatty acids have well documented properties which would reduce the cardiovascular (CV) disease risk, the evidence from randomized controlled trials (RCTs) remains inconclusive. We performed a meta-analysis of the available RCTs for investigating the CV preventive effect of administrating at least 1 gram/day, and for at least 1 year, omega-3 fatty acid supplements to patients with existing CV disease.
Methods
RCTs published up to March 2013 were searched from PubMed, EMBASE, and the Cochrane Library. Two of us independently reviewed and selected eligible trials.
Results
Of 360 articles retrieved, 11 randomized, double-blind, placebo controlled trials fulfilling inclusion criteria, overall involving 15,348 patients with a history of CV disease, were considered in the final analyses. No statistically significant association was observed for all-cause mortality (RR, 0.89; 95% CI, 0.78 to 1.02) and stroke (RR, 1.31; 95% CI, 0.90 to 1.90). Conversely, statistically significant protective effects were observed for cardiac death (RR, 0.68; 95% CI, 0.56 to 0.83), sudden death (RR, 0.67; 95% CI, 0.52 to 0.87), and myocardial infarction (RR, 0.75; 95% CI, 0.63 to 0.88).
Conclusion
Overall, our results supply evidence that long-term effect of high dose omega-3 fatty acid supplementation may be beneficial for the onset of cardiac death, sudden death and myocardial infarction among patients with a history of cardiovascular disease.
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