Fish-oil fat emulsion supplementation reduces the risk of retinopathy in very low birth weight infants: a prospective, randomized study
Pawlik D, Lauterbach R, Walczak M, Hurkała J, Sherman MP
JPEN. Journal of parenteral and enteral nutrition · 95 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-08-20 · JPEN J Parenter Enteral Nutr · vol. 38 · número 6 · págs. 711–716
- Editorial
- Wiley
- Citado
- 124 citas · más que el 98% de estudios similares · 9.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · CC-BY-NC-ND
- Áreas de investigación
- Fatty Acid Research and Health · Retinopathy of Prematurity Studies · Infant Nutrition and Health
- Palabras clave
- fish oil, lipid emulsions, retinopathy of prematurity, very low birth weight infants, preterm infants, docosahexaenoic acid, cholestasis, Intralipid, parenteral nutrition, laser therapy
- MeSH
- humans, cholestasis, retinopathy of prematurity, docosahexaenoic acids, soybean oil, fat emulsions, intravenous, phospholipids, fish oils, plant oils, emulsions, treatment outcome, parenteral nutrition, prospective studies, child development, infant, newborn, infant, very low birth weight, infant, premature, female, male, olive oil
5 autores
- Dorota Pawlik🇵🇱Jagiellonian University
- Ryszard Lauterbach🇵🇱 · autor de correspondenciaJagiellonian University
- Maria Walczak🇵🇱Jagiellonian University
- Joanna Hurkała🇵🇱Jagiellonian University
- Michael P. Sherman🇺🇸University of Missouri
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Preliminary studies suggest that fish-oil lipid emulsion given parenterally to very preterm infants reduces the severity of retinopathy (ROP) and cholestasis.
Methods
Infants weighing <1250 g at birth were randomly allocated to 2 groups: an experimental group of 60 infants that received an intravenous (IV) soybean, olive oil, and fish oil emulsion, and a control group of 70 infants that was given a parenteral soybean and olive oil emulsion. Plasma and erythrocyte concentrations of docosahexaenoic acid (DHA) were determined using a high-performance liquid chromatography-mass spectrometry analysis.
Results
Nine infants in the fish oil group required laser therapy for ROP compared with 22 infants in the standard intralipid group (risk ratio [RR], 0.48; 95% confidence interval [CI], 0.24-0.96). Three infants in the fish oil group developed cholestasis compared with 20 infants in the standard intralipid group (RR, 0.18; 95% CI, 0.055-0.56). The mean plasma DHA concentrations in treated infants were 2.9-fold higher in the fish oil group than in control infants on the 7th and 14th days of life. The mean DHA content in erythrocytes of treated infants was 4.5-fold and 2.7-fold higher compared with controls at 7 and 14 days of age.
Conclusions
Premature infants receiving an IV fat emulsion containing fish oil had less ROP requiring laser treatment and less cholestasis than those receiving a standard lipid emulsion. These infants also had higher plasma and erythrocyte DHA levels at 7 and 14 days, suggesting potential long-term neurodevelopmental benefits.
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