A diet rich in high-glucoraphanin broccoli interacts with genotype to reduce discordance in plasma metabolite profiles by modulating mitochondrial function
Armah CN, Traka MH, Dainty JR, Defernez M, Janssens A, Leung W, Doleman JF, Potter JF, Mithen RF
The American journal of clinical nutrition · 53 citas
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Vínculos de autores con la industriaAlimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Prostate Cancer Foundation
- Gobierno
- Directorate for Biological Sciences
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Autores
- Al menos un autor declara un vínculo económico con la industria
- Subvenciones
- Biotechnology and Biological Sciences Research Council (BBS/E/F/00044431); Biotechnology and Biological Sciences Research Council (BBS/E/F/00044431); Biotechnology and Biological Sciences Research Council (BB/J004545/1)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-08-20 · Am J Clin Nutr · vol. 98 · número 3 · págs. 712–722
- Editorial
- Elsevier BV
- Citado
- 77 citas · más que el 94% de estudios similares · 3.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 57 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Liver Disease Diagnosis and Treatment · Alcohol Consumption and Health Effects
- Palabras clave
- Glucoraphanin, Metabolite, Metabolome, Sulforaphane, Genotype, Biology, Metabolomics, Cruciferous vegetables, Internal medicine, Endocrinology, Food science, Chemistry, Biochemistry, Medicine, Bioinformatics, Brassica, Glucosinolate, Botany, Cancer, Gene
- MeSH
- mitochondria, humans, brassica, cardiovascular diseases, oximes, imidoesters, sulfoxides, nucleotidyltransferases, glucosinolates, lipids, amino acids, plant extracts, diet, multivariate analysis, sex factors, genotype, polymorphism, single nucleotide, aged, middle aged, female, male, metabolome, biomarkers
9 autores
- Charlotte N. Armah🇬🇧Norwich Research Park; Quadram Institute
- Μαρία Τράκα🇬🇧University of East Anglia; Norwich Research Park
- Jack R. Dainty🇬🇧University of East Anglia; Norwich Research Park
- Marianne Defernez🇬🇧University of East Anglia; Norwich Research Park
- Astrid Janssens🇬🇧University of East Anglia; Norwich Research Park
- W. Leung🇬🇧University of East Anglia
- Joanne F. Doleman🇬🇧University of East Anglia
- John F. Potter🇬🇧University of East Anglia; Norwich Research Park
- Richard F. Mithen🇬🇧University of East Anglia; Norwich Research Park
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Observational and experimental studies suggest that diets rich in cruciferous vegetables and glucosinolates may reduce the risk of cancer and cardiovascular disease (CVD).
Objective
We tested the hypothesis that a 12-wk dietary intervention with high-glucoraphanin (HG) broccoli would modify biomarkers of CVD risk and plasma metabolite profiles to a greater extent than interventions with standard broccoli or peas.
Design
Subjects were randomly assigned to consume 400 g standard broccoli, 400 g HG broccoli, or 400 g peas each week for 12 wk, with no other dietary restrictions. Biomarkers of CVD risk and 347 plasma metabolites were quantified before and after the intervention.
Results
No significant differences in the effects of the diets on biomarkers of CVD risk were found. Multivariate analyses of plasma metabolites identified 2 discrete phenotypic responses to diet in individuals within the HG broccoli arm, differentiated by single nucleotide polymorphisms associated with the PAPOLG gene. Univariate analysis showed effects of sex (P < 0.001), PAPOLG genotype (P < 0.001), and PAPOLG genotype × diet (P < 0.001) on the plasma metabolic profile. In the HG broccoli arm, the consequence of the intervention was to reduce variation in lipid and amino acid metabolites, tricarboxylic acid (TCA) cycle intermediates, and acylcarnitines between the 2 PAPOLG genotypes.
Conclusions
The metabolic changes observed with the HG broccoli diet are consistent with a rebalancing of anaplerotic and cataplerotic reactions and enhanced integration of fatty acid β-oxidation with TCA cycle activity. These modifications may contribute to the reduction in cancer risk associated with diets that are rich in cruciferous vegetables. This trial was registered at clinicaltrials.gov as NCT01114399.
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