Red and processed meat intake is associated with higher gastric cancer risk: a meta-analysis of epidemiological observational studies
Zhu H, Yang X, Zhang C, Zhu C, Tao G, Zhao L, Tang S, Shu Z, Cai J, Dai S, Qin Q, Xu L, Cheng H, Sun X
PloS one · 90 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Natural Science Foundation of China
- Gobierno
- Government of Jiangsu Province
- Organización sin fines de lucro
- Chinese Society of Clinical Oncology
- Subvenciones
- National Natural Science Foundation of China (BRA2012210); National Natural Science Foundation of China (81272504)
Según 3 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-08-14 · PLoS One · vol. 8 · número 8 · pág. e70955
- Editorial
- Public Library of Science
- Citado
- 116 citas · más que el 83% de estudios similares · 1.9× el promedio de su campo
- Referencias
- 73 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Nutritional Studies and Diet · Agriculture Sustainability and Environmental Impact · Colorectal Cancer Screening and Detection
- Palabras clave
- Observational study, Epidemiology, Medicine, Cancer, Environmental health, Internal medicine, Biology, Bioinformatics
- MeSH
- humans, stomach neoplasms, risk, epidemiologic studies, eating, food handling, meat, observational studies as topic
14 autores
- Hongcheng Zhu🇨🇳Jiangsu Province Hospital; Nanjing Medical University
- Xi Yang🇨🇳Jiangsu Province Hospital; Nanjing Medical University
- Chi Zhang🇨🇳Jiangsu Province Hospital; Nanjing Medical University
- Chen Ying Zhu🇨🇳Nanjing Medical University
- Guangzhou Tao🇨🇳Huaian First People’s Hospital; Nanjing Medical University
- Lianjun Zhao🇨🇳Nanjing Drum Tower Hospital; Nanjing Medical University
- Shaowen Tang🇨🇳Nanjing Medical University
- Shu Sen Zheng🇨🇳Peking University
- Jing Cai🇨🇳Nantong Tumor Hospital
- Shengbin Dai🇨🇳Nantong University; Taizhou People's Hospital
- Qin Qin🇨🇳Jiangsu Province Hospital; Nanjing Medical University
- Liping Xu🇨🇳Jiangsu Province Hospital; Nanjing Medical University
- Hongyan Cheng🇨🇳 · autor de correspondenciaJiangsu Province Hospital; Nanjing Medical University
- Xinchen Sun🇨🇳 · autor de correspondenciaJiangsu Province Hospital; Nanjing Medical University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Red and processed meat was concluded as a limited-suggestive risk factor of gastric cancer by the World Cancer Research Fund. However, recent epidemiological studies have yielded inconclusive results.
Methods
We searched Medline, EMBASE, and the Cochrane Library from their inception to April 2013 for both cohort and case-control studies which assessed the association between red and/or processed meat intake and gastric cancer risk. Study-specific relative risk estimates were polled by random-effect or fixed-effect models.
Results
Twelve cohort and thirty case-control studies were included in the meta-analysis. Significant associations were found between both red (RR: 1.45, 95% CI: 1.22-1.73) and processed (RR: 1.45, 95% CI: 1.26-1.65) meat intake and gastric cancer risk generally. Positive findings were also existed in the items of beef (RR: 1.28, 95% CI: 1.04-1.57), bacon (RR: 1.37, 95% CI: 1.17-1.61), ham (RR: 1.44, 95% CI: 1.00-2.06), and sausage (RR: 1.33, 95% CI: 1.16-1.52). When conducted by study design, the association was significant in case-control studies (RR: 1.63, 95% CI: 1.33-1.99) but not in cohort studies (RR: 1.02, 95% CI: 0.90-1.17) for red meat. Increased relative risks were seen in high-quality, adenocarcinoma, cardia and European-population studies for red meat. And most subgroup analysis confirmed the significant association between processed meat intake and gastric cancer risk.
Conclusions
Our findings indicate that consumption of red and/or processed meat contributes to increased gastric cancer risk. However, further investigation is needed to confirm the association, especially for red meat.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.