Intake and time dependence of blueberry flavonoid-induced improvements in vascular function: a randomized, controlled, double-blind, crossover intervention study with mechanistic insights into biological activity
Rodriguez-Mateos A, Rendeiro C, Bergillos-Meca T, Tabatabaee S, George TW, Heiss C, Spencer JP
The American journal of clinical nutrition · 276 citas
Etiquetas de revisión
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Biotechnology and Biological Sciences Research Council
- Subvenciones
- Biotechnology and Biological Sciences Research Council (BB/F008953/1); Biotechnology and Biological Sciences Research Council (BB/F008953/1)
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-09-05 · Am J Clin Nutr · vol. 98 · número 5 · págs. 1179–1191
- Editorial
- Elsevier BV
- Citado
- 361 citas · más que el 100% de estudios similares · 16.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 68 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Nitric Oxide and Endothelin Effects · Cardiovascular Health and Disease Prevention
- Palabras clave
- blueberry polyphenols, endothelial function, flow-mediated dilation, vascular function, neutrophil NADPH oxidase, dose-response relationship, time-dependent effects, acute dietary intervention
- MeSH
- brachial artery, humans, anthocyanins, endpoint determination, chromatography, liquid, cross-over studies, double-blind method, vasodilation, adolescent, adult, male, mass spectrometry, young adult, polyphenols, hydroxybenzoates, pulse wave analysis, blueberry plants, nadph oxidases
7 autores
- Ana Rodriguez‐Mateos🇬🇧🇩🇪Northumbria University; Heinrich Heine University Düsseldorf; University of Reading
- Catarina Rendeiro🇩🇪Heinrich Heine University Düsseldorf
- Triana Bergillos-Meca🇬🇧Northumbria University
- Setareh Tabatabaee
- Trevor W. George🇬🇧Northumbria University
- Christian Heiß
- Jeremy P.E. Spencer🇬🇧King's College London
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
There are very limited data regarding the effects of blueberry flavonoid intake on vascular function in healthy humans.
Objectives
We investigated the impact of blueberry flavonoid intake on endothelial function in healthy men and assessed potential mechanisms of action by the assessment of circulating metabolites and neutrophil NADPH oxidase activity.
Design
Two randomized, controlled, double-blind, crossover human-intervention trials were conducted with 21 healthy men. Initially, the impact of blueberry flavonoid intake on flow-mediated dilation (FMD) and polyphenol absorption and metabolism was assessed at baseline and 1, 2, 4, and 6 h after consumption of blueberry containing 766, 1278, and 1791 mg total blueberry polyphenols or a macronutrient- and micronutrient-matched control drink (0 mg total blueberry polyphenols). Second, an intake-dependence study was conducted (from baseline to 1 h) with 319, 637, 766, 1278, and 1791 mg total blueberry polyphenols and a control.
Results
We observed a biphasic time-dependent increase in FMD, with significant increases at 1-2 and 6 h after consumption of blueberry polyphenols. No significant intake-dependence was observed between 766 and 1791 mg. However, at 1 h after consumption, FMD increased dose dependently to ≤766 mg total blueberry polyphenol intake, after which FMD plateaued. Increases in FMD were closely linked to increases in circulating metabolites and by decreases in neutrophil NADPH oxidase activity at 1-2 and 6 h.
Conclusions
Blueberry intake acutely improves vascular function in healthy men in a time- and intake-dependent manner. These benefits may be mechanistically linked to the actions of circulating phenolic metabolites on neutrophil NADPH oxidase activity. This trial was registered at clinicaltrials.gov as NCT01292954 and NCT01829542.
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