Caffeine does not increase the risk of atrial fibrillation: a systematic review and meta-analysis of observational studies
Caldeira D, Martins C, Alves LB, Pereira H, Ferreira JJ, Costa J
Heart (British Cardiac Society) · 72 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-09-05 · Heart · vol. 99 · número 19 · págs. 1383–1389
- Editorial
- BMJ
- Citado
- 109 citas · más que el 86% de estudios similares · 2.0× el promedio de su campo
- Referencias
- 54 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coffee research and impacts · Atrial Fibrillation Management and Outcomes · Cardiac electrophysiology and arrhythmias
- Palabras clave
- caffeine, atrial fibrillation, coffee consumption, caffeine dose, arrhythmia risk factors
- MeSH
- humans, atrial fibrillation, caffeine, odds ratio, risk assessment, risk factors, dose-response relationship, drug, coffee, middle aged, female, male
6 autores
- Daniel Caldeira🇵🇹 · autor de correspondenciaUniversity of Lisbon; Laboratório de Farmacologia Clínica e Terapêutica
- Cristina Martins🇵🇹Hospital Garcia de Orta
- Luís Brandão Alves🇵🇹Hospital Garcia de Orta
- Hélder Pereira🇵🇹Hospital Garcia de Orta
- Joaquim José Ferreira🇵🇹University of Lisbon; Instituto de Medicina Molecular João Lobo Antunes
- João N. Costa🇵🇹University of Lisbon
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Atrial fibrillation (AF) is the most prevalent sustained arrhythmia, and risk factors are well established. Caffeine exposure has been associated with increased risk of AF, but heterogeneous data exist in the literature.
Objective
To evaluate the association between chronic exposure to caffeine and AF.
Design
Systematic review and meta-analysis of observational studies.
Data sources
PubMed, CENTRAL, ISI Web of Knowledge and LILACS to December 2012. Reviews and references of retrieved articles were comprehensively searched.
Study selection
Two reviewers independently searched for studies and retrieved their characteristics and data estimates.
Data synthesis
Random-effects meta-analysis was performed, and pooled estimates were expressed as OR and 95% CI. Heterogeneity was assessed with the I(2) test. Subgroup analyses were conducted according to caffeine dose and source (coffee).
Results
Seven observational studies evaluating 115 993 individuals were included: six cohorts and one case-control study. Caffeine exposure was not associated with an increased risk of AF (OR 0.92, 95% CI 0.82 to 1.04, I(2)=72%). Pooled results from high-quality studies showed a 13% odds reduction in AF risk with lower heterogeneity (OR 0.87; 95% CI 0.80 to 0.94; I(2)=39%). Low-dose caffeine exposure showed OR 0.85 (95% CI 0.78 to 92, I(2)=0%) without significant differences in other dosage strata. Caffeine exposure based solely on coffee consumption also did not influence AF risk.
Conclusions
Caffeine exposure is not associated with increased AF risk. Low-dose caffeine may have a protective effect.
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