Vitamin D intake and risk of type 1 diabetes: a meta-analysis of observational studies
Dong JY, Zhang WG, Chen JJ, Zhang ZL, Han SF, Qin LQ
Nutrients · 130 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Chinese Nutrition Society
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-09-12 · Nutrients · vol. 5 · número 9 · págs. 3551–3562
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 207 citas · más que el 88% de estudios similares · 2.2× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Vitamin D Research Studies · Diabetes and associated disorders · Nutritional Studies and Diet
- Palabras clave
- vitamin D, type 1 diabetes, vitamin D supplementation, early life, pregnancy, diabetes risk, observational studies
- MeSH
- humans, diabetes mellitus, type 1, vitamins, vitamin d, odds ratio, risk factors, dietary supplements, databases, factual, observational studies as topic
6 autores
- Jiayi Dong🇨🇳Soochow University
- Weiguo Zhang
- Jiong Chen
- Zengli Zhang🇨🇳Soochow University
- Shu-Fen Han🇨🇳Soochow University
- Li‐Qiang Qin🇨🇳 · autor de correspondenciaSoochow University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Vitamin D is suggested to have protective effects against type 1 diabetes. However, the results from observational studies have been inconsistent. We aimed to examine their association by conducting a meta-analysis of observational studies. Multiple databases were searched in June 2013 to identify relevant studies including both case-control and cohort studies. Either a fixed- or random-effects model was used to calculate the pooled risk estimate. We identified eight studies (two cohort studies and six case-control studies) on vitamin D intake during early life and three studies (two cohort studies and one case-control study) on maternal vitamin D intake during pregnancy. The pooled odds ratio for type 1 diabetes comparing vitamin D supplementation with non-supplementation during early life was 0.71 (95% confidence interval [CI], 0.51-0.98). Similar results were observed in the case-control subgroup analysis but not in the cohort subgroup analysis. The pooled odds ratio with maternal intake of vitamin D during pregnancy was 0.95 (95% CI, 0.66-1.36). In conclusion, vitamin D intake during early life may be associated with a reduced risk of type 1 diabetes. However, there was not enough evidence for an association between maternal intake of vitamin D and risk of type 1 diabetes in the offspring.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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