Phase III trial of low-level laser therapy to prevent oral mucositis in head and neck cancer patients treated with concurrent chemoradiation
Antunes HS, Herchenhorn D, Small IA, Araújo CM, Viégas CM, Cabral E, Rampini MP, Rodrigues PC, Silva TG, Ferreira EM, Dias FL, Ferreira CG
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology · 100 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-09-14 · Radiother Oncol · vol. 109 · número 2 · págs. 297–302
- Editorial
- Elsevier BV
- Citado
- 137 citas · más que el 97% de estudios similares · 6.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 43 trabajos
- Acceso
- De pago
- Áreas de investigación
- Oral health in cancer treatment · Laser Applications in Dentistry and Medicine · Head and Neck Cancer Studies
- Palabras clave
- low-level laser therapy, oral mucositis, head and neck squamous cell carcinoma, chemoradiotherapy, cisplatin, diode laser, mucositis prevention, quality of life, radiotherapy complications
- MeSH
- humans, carcinoma, squamous cell, head and neck neoplasms, stomatitis, prospective studies, double-blind method, quality of life, aged, middle aged, female, male, chemoradiotherapy, low-level light therapy, squamous cell carcinoma of head and neck
12 autores
- Héliton Spíndola Antunes🇧🇷Instituto Nacional de Câncer - INCA
- Daniel Herchenhorn🇧🇷Instituto Nacional de Câncer - INCA
- Isabele Avila Small🇧🇷Instituto Nacional de Câncer - INCA
- Carlos M. Araújo🇧🇷Instituto Nacional de Câncer - INCA
- Celia Maria Pais Viegas🇧🇷Instituto Nacional de Câncer - INCA
- Elida Cabral🇧🇷Instituto Nacional de Câncer - INCA
- Mariana Pereira Rampini🇧🇷Instituto Nacional de Câncer - INCA
- Pedro Carvalho Rodrigues🇧🇷Instituto Nacional de Câncer - INCA
- Tereza G.P. Silva🇧🇷Instituto Nacional de Câncer - INCA
- Elza Maria de Sá Ferreira
- Fernando Luiz Dias🇧🇷Instituto Nacional de Câncer - INCA
- Carlos Gil Ferreira🇧🇷Instituto Nacional de Câncer - INCA
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Oral mucositis (OM) is a complication of chemoradiotherapy treatment of head and neck squamous cell carcinoma (HNSCC) patients with no effective therapy. This study was designed to assess the efficacy of preventive low-level laser therapy (LLLT) in reducing the incidence of grade 3-4 OM.
Material and methods
From June 2007 to December 2010, 94 HNSCC patients entered a prospective, randomized, double-blind, placebo-controlled phase III trial. Chemoradiotherapy consisted of conventional radiotherapy plus concurrent cisplatin every 3weeks. A diode InGaAlP (660nm-100mW-1J-4J/cm(2)) was used. OM evaluation was performed by WHO and OMAS scales and quality of life by EORTC questionnaires (QLQ).
Results
A six-fold decrease in the incidence of grades 3-4 OM was detected in the LLLT group compared to the placebo; (6.4% versus 40.5%). LLLT impacted the incidence of grades 3-4 OM to a relative risk ratio of 0.158 (CI 95% 0.050-0.498). After treatment QLQ-C30 showed, differences favoring LLLT in physical, emotional functioning, fatigue, and pain; while the QLQ-H&N35 showed improvements in LLLT arm for pain, swallowing, and trouble with social eating.
Conclusion
Preventive LLLT in HNSCC patients receiving chemoradiotherapy is an effective tool for reducing the incidence of grade 3-4 OM. Efficacy data were corroborated by improvements seen in quality of life.
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