Fish Oil (SMOFlipid) and olive oil lipid (Clinoleic) in very preterm neonates
Deshpande G, Simmer K, Deshmukh M, Mori TA, Croft KD, Kristensen J
Journal of pediatric gastroenterology and nutrition · 59 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-09-17 · J Pediatr Gastroenterol Nutr · vol. 58 · número 2 · págs. 177–182
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 88 citas · más que el 94% de estudios similares · 4.0× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 35 trabajos
- Acceso
- De pago
- Áreas de investigación
- Neonatal Respiratory Health Research · Infant Nutrition and Health · Clinical Nutrition and Gastroenterology
- Palabras clave
- Docosahexaenoic acid, Fish oil, Polyunsaturated fatty acid, Eicosapentaenoic acid, Soybean oil, Medicine, Food science, Linoleic acid, Fatty acid, Lipid peroxidation, Internal medicine, Biochemistry, Oxidative stress, Chemistry, Biology, Fishery, Fish <Actinopterygii>
- MeSH
- humans, vitamin e, docosahexaenoic acids, eicosapentaenoic acid, soybean oil, fat emulsions, intravenous, fatty acids, unsaturated, f2-isoprostanes, linoleic acid, oleic acid, fish oils, plant oils, parenteral nutrition, total, lipid peroxidation, oxidative stress, infant, newborn, female, male, infant, extremely premature, olive oil, coconut oil
6 autores
- Girish C. Deshpande🇦🇺 · autor de correspondenciaKing Edward Memorial Hospital
- Karen Norrie Simmer🇦🇺 · autor de correspondenciaKing Edward Memorial Hospital
- Mangesh Deshmukh🇦🇺 · autor de correspondenciaKing Edward Memorial Hospital
- Trevor Anthony Mori🇦🇺The University of Western Australia
- Kevin D. Croft🇦🇺The University of Western Australia
- Judy Kristensen🇦🇺King Edward Memorial Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Fat emulsions used in Australia for parenteral nutrition in preterm neonates have been based on either soybean oil or olive oil (OO). OO lipid Clinoleic has a high ratio of n-6 to n-3 fatty acids (9:1); this may not be ideal for long-chain polyunsaturated fatty acids supply. Newly available SMOFlipid has an appropriate ratio of n-6 to n-3 fatty acids (2.5:1). SMOFlipid also contains OO (25%), coconut oil (30%), and soybean oil (30%). The aims of the study were to evaluate the safety of the SMOFlipid and to test the hypothesis that SMOFlipid would lead to increased omega-3 long-chain polyunsaturated fatty acid levels and reduced oxidative stress as compared with Clinoleic in preterm neonates (<30 weeks).
Methods
Preterm neonates (23-30 weeks) were randomised to receive Clinoleic or SMOFlipid emulsion for 7 days. Investigators and outcome assessors were masked to allocation. Plasma F2-isoprostanes (lipid peroxidation marker), red blood cell fatty acids, and vitamin E were measured before and after the study. Blood culture positive sepsis and growth were monitored for safety.
Results
Thirty of 34 participants completed the study. Both emulsions were well tolerated without any adverse events. F2-isoprostane levels were reduced in the SMOFlipid group as compared with baseline. Eicosapentanoic acid and vitamin E levels were significantly increased in the SMOFlipid group. Oleic acid and linoleic acid levels were increased in both groups. No significant differences were noted in poststudy docosahexaenoic acid levels in both groups despite higher levels of docosahexaenoic acid in SMOFlipid.
Conclusions
SMOFlipid was safe, well tolerated, and showed beneficial effect in terms of reduction of oxidative stress by reducing lipid peroxidation levels in high-risk preterm neonates.
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