Dietary magnesium intake improves insulin resistance among non-diabetic individuals with metabolic syndrome participating in a dietary trial
Wang J, Persuitte G, Olendzki BC, Wedick NM, Zhang Z, Merriam PA, Fang H, Carmody J, Olendzki GF, Ma Y
Nutrients · 22 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Center for Research Resources
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NCRR NIH HHS
- Gobierno
- NCATS NIH HHS
- Subvenciones
- National Heart, Lung, and Blood Institute (R01 HL094575); National Heart, Lung, and Blood Institute (5R01HL094575-04); National Institutes of Health (UL1TR000161); National Center for Research Resources (UL1RR031982)
Según 7 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-09-27 · Nutrients · vol. 5 · número 10 · págs. 3910–3919
- Editorial
- Multidisciplinary Digital Publishing Institute
- Citado
- 51 citas · más que el 90% de estudios similares · 2.9× el promedio de su campo
- Referencias
- 34 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, insulin resistance, metabolic syndrome, RDA, HOMA-IR, fasting blood glucose, fasting insulin, non-diabetic adults, dietary intervention
- MeSH
- humans, diabetes mellitus, insulin resistance, magnesium, insulin, blood glucose, diet, nutrition assessment, multivariate analysis, odds ratio, longitudinal studies, mental recall, adult, middle aged, female, male, recommended dietary allowances, metabolic syndrome
10 autores
- Jinsong Wang🇺🇸🇨🇳University of Massachusetts Chan Medical School; Yangzhou University
- Gioia M. Persuitte🇺🇸University of Massachusetts Chan Medical School
- Barbara C. Olendzki🇺🇸University of Massachusetts Chan Medical School
- Nicole M. Wedick🇺🇸University of Massachusetts Chan Medical School
- Zhiying Zhang🇺🇸University of Massachusetts Chan Medical School
- Philip A. Merriam🇺🇸University of Massachusetts Chan Medical School
- Hua Fang🇺🇸University of Massachusetts Chan Medical School
- James Carmody🇺🇸University of Massachusetts Chan Medical School
- Gin-Fei Olendzki🇺🇸University of Massachusetts Chan Medical School
- Yunsheng Ma🇺🇸 · autor de correspondenciaUniversity of Massachusetts Chan Medical School
Resumen
El texto original del estudio, en el idioma en que se publicó.
Many cross-sectional studies show an inverse association between dietary magnesium and insulin resistance, but few longitudinal studies examine the ability to meet the Recommended Dietary Allowance (RDA) for magnesium intake through food and its effect on insulin resistance among participants with metabolic syndrome (MetS). The dietary intervention study examined this question in 234 individuals with MetS. Magnesium intake was assessed using 24-h dietary recalls at baseline, 6, and 12 months. Fasting glucose and insulin levels were collected at each time point; and insulin resistance was estimated by the homeostasis model assessment (HOMA-IR). The relation between magnesium intake and HOMA-IR was assessed using linear mixed models adjusted for covariates. Baseline magnesium intake was 287 ± 93 mg/day (mean ± standard deviation), and HOMA-IR, fasting glucose and fasting insulin were 3.7 ± 3.5, 99 ± 13 mg/dL, and 15 ± 13 μU/mL, respectively. At baseline, 6-, and 12-months, 23.5%, 30.4%, and 27.7% met the RDA for magnesium. After multivariate adjustment, magnesium intake was inversely associated with metabolic biomarkers of insulin resistance (P 3.6) over time was 71% lower [odds ratio (OR): 0.29; 95% confidence interval (CI): 0.12, 0.72] in participants in the highest quartile of magnesium intake than those in the lowest quartile. For individuals meeting the RDA for magnesium, the multivariate-adjusted OR for high HOMA-IR over time was 0.37 (95% CI: 0.18, 0.77). These findings indicate that dietary magnesium intake is inadequate among non-diabetic individuals with MetS and suggest that increasing dietary magnesium to meet the RDA has a protective effect on insulin resistance.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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