Creatine supplementation associated or not with strength training upon emotional and cognitive measures in older women: a randomized double-blind study
Alves CR, Merege Filho CA, Benatti FB, Brucki S, Pereira RM, de Sá Pinto AL, Lima FR, Roschel H, Gualano B
PloS one · 58 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Fundação de Amparo à Pesquisa do Estado de São Paulo
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-10-03 · PLoS One · vol. 8 · número 10 · pág. e76301
- Editorial
- Public Library of Science
- Citado
- 107 citas · más que el 88% de estudios similares · 2.6× el promedio de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Muscle metabolism and nutrition · Nutrition and Health in Aging · Biochemical effects in animals
- Palabras clave
- creatine supplementation, resistance training, older women, cognitive function, emotional state, depression, muscle strength, dietary intake, memory, selective attention, inhibitory control
- MeSH
- humans, creatine, treatment outcome, diet, double-blind method, emotions, cognition, neuropsychological tests, age factors, dietary supplements, aged, aged, 80 and over, middle aged, female, muscle strength, resistance training, medication adherence, self report
9 autores
- Christiano R. R. Alves🇧🇷Universidade de São Paulo
- Carlos Alberto Abujabra Merege Filho🇧🇷Universidade de São Paulo
- Fabiana Braga Benatti🇧🇷Universidade de São Paulo
- Sônia Maria Dozzi Brucki🇧🇷Universidade de São Paulo
- Rosa Maria Rodrigues Pereira🇧🇷Universidade de São Paulo
- Ana Lúcia de Sá Pinto🇧🇷Universidade de São Paulo
- Fernanda Rodrigues Lima🇧🇷Universidade de São Paulo
- Hamilton Roschel🇧🇷Universidade de São Paulo
- Bruno Gualano🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
To assess the effects of creatine supplementation, associated or not with strength training, upon emotional and cognitive measures in older woman.
Methods
This is a 24-week, parallel-group, double-blind, randomized, placebo-controlled trial. The individuals were randomly allocated into one of the following groups (n=14 each): 1) placebo, 2) creatine supplementation, 3) placebo associated with strength training or 4) creatine supplementation associated with strength training. According to their allocation, the participants were given creatine (4 x 5 g/d for 5 days followed by 5 g/d) or placebo (dextrose at the same dosage) and were strength trained or not. Cognitive function, assessed by a comprehensive battery of tests involving memory, selective attention, and inhibitory control, and emotional measures, assessed by the Geriatric Depression Scale, were evaluated at baseline, after 12 and 24 weeks of the intervention. Muscle strength and food intake were evaluated at baseline and after 24 weeks.
Results
After the 24-week intervention, both training groups (ingesting creatine supplementation and placebo) had significant reductions on the Geriatric Depression Scale scores when compared with the non-trained placebo group (p = 0.001 and p = 0.01, respectively) and the non-trained creatine group (p < 0.001 for both comparison). However, no significant differences were observed between the non-trained placebo and creatine (p = 0.60) groups, or between the trained placebo and creatine groups (p = 0.83). Both trained groups, irrespective of creatine supplementation, had better muscle strength performance than the non-trained groups. Neither strength training nor creatine supplementation altered any parameter of cognitive performance. Food intake remained unchanged.
Conclusion
Creatine supplementation did not promote any significant change in cognitive function and emotional parameters in apparently healthy older individuals. In addition, strength training per se improved emotional state and muscle strength, but not cognition, with no additive effects of creatine supplementation.
Trial registration
Clinicaltrials.gov NCT01164020.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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