Polymorphisms in xenobiotic metabolizing genes, intakes of heterocyclic amines and red meat, and postmenopausal breast cancer
Lee HJ, Wu K, Cox DG, Hunter D, Hankinson SE, Willett WC, Sinha R, Cho E
Nutrition and cancer · 13 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoMezcla carne procesada con no procesadaSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (P01 CA087969); National Cancer Institute (CA-87969)
Según 3 financiadores declarados.
Publicación
- Publicado
- 2013-10-07 · Nutr Cancer · vol. 65 · número 8 · págs. 1122–1131
- Editorial
- Routledge
- Citado
- 20 citas · más que el 86% de estudios similares · 2.3× el promedio de su campo
- Referencias
- 55 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Effects and risks of endocrine disrupting chemicals · Nutrition, Genetics, and Disease · Carcinogens and Genotoxicity Assessment
- Palabras clave
- Xenobiotic, Breast cancer, Gene, Heterocyclic amine, Postmenopausal women, Cancer, Medicine, Red meat, Genetics, Internal medicine, Physiology, Biology, Food science, Carcinogen, Biochemistry
- MeSH
- humans, breast neoplasms, amines, cytochrome p-450 cyp1a2, arylamine n-acetyltransferase, xenobiotics, mutagens, risk factors, case-control studies, follow-up studies, prospective studies, temperature, acetylation, postmenopause, polymorphism, genetic, meat, middle aged, female, hot temperature, cooking, surveys and questionnaires
8 autores
- Hae‐Jeung Lee🇺🇸🇰🇷Brigham and Women's Hospital; Harvard University; Korea Health Industry Development Institute
- Kana Wu🇺🇸Harvard University
- David G. Cox🇫🇷Inserm; Centre de Recherche en Cancérologie de Lyon
- David John Hunter🇺🇸Brigham and Women's Hospital; Harvard University
- Susan E. Hankinson🇺🇸Brigham and Women's Hospital; Harvard University
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Rashmi R. Sinha🇺🇸National Institutes of Health; National Cancer Institute
- Eunyoung Cho🇺🇸Brigham and Women's Hospital; Harvard University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Heterocyclic amines (HCAs) are mutagenic compounds generated when meats are cooked at high temperature and for long duration. The findings from previous studies on the relation between HCAs and breast cancer are inconsistent, possibly because of genetic variations in the enzymes metabolizing HCAs. To evaluate whether the associations of intakes of estimated HCAs, meat-derived mutagenicity (MDM), and red meat with risk of postmenopausal breast cancer were modified by N-acetyltransferase 2 (NAT2) acetylator genotype or cytochrome P450 1A2-164 A/C (CYP1A2) polymorphism, we conducted a nested case-control study with 579 cases and 981 controls within a prospective cohort, the Nurses' Health Study. HCAs and MDM intakes were derived using a cooking method questionnaire administered in 1996. NAT2acetylator genotype, the CYP1A2 polymorphism, and intakes of HCAs, MDM, and red meat were not associated with risk of postmenopausal breast cancer. There was also no interaction between NAT2 acetylator genotype or CYP1A2 polymorphism and HCAs and MDM and red meat intake in relation to breast cancer. These results do not support the hypothesis that genetic polymorphisms of xenobiotic enzymes involved in the metabolism of HCAs may modify the associations between intakes of red meat or meat-related mutagens and breast cancer risk.
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