A randomized study on the effect of vitamin D₃ supplementation on skeletal muscle morphology and vitamin D receptor concentration in older women
Ceglia L, Niramitmahapanya S, da Silva Morais M, Rivas DA, Harris SS, Bischoff-Ferrari H, Fielding RA, Dawson-Hughes B
The Journal of clinical endocrinology and metabolism · 189 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute on Aging
- Gobierno
- National Center for Research Resources
- Gobierno
- NIA NIH HHS
- Gobierno
- NCRR NIH HHS
- Subvenciones
- National Center for Research Resources (KL-2 RR025751); National Institute on Aging (P30-AG031679)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-10-10 · J Clin Endocrinol Metab · vol. 98 · número 12 · págs. E1927–E1935
- Editorial
- Oxford University Press
- Citado
- 257 citas · más que el 99% de estudios similares · 14.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 33 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Nutrition and Health in Aging · Muscle Physiology and Disorders
- Palabras clave
- vitamin D3 supplementation, vitamin D receptor, skeletal muscle morphology, muscle fiber cross-sectional area, older women, 25-hydroxyvitamin D, muscle fiber type, vastus lateralis, muscle mass, vitamin D deficiency, Short Physical Performance Battery, fall risk, sarcopenia, frailty
- MeSH
- muscle fibers, fast-twitch, muscle fibers, slow-twitch, humans, vitamin d deficiency, cholecalciferol, calcifediol, receptors, calcitriol, geriatric assessment, cohort studies, pilot projects, double-blind method, anatomy, cross-sectional, up-regulation, aging, muscle development, dietary supplements, aged, aged, 80 and over, female, mobility limitation, quadriceps muscle, muscle strength
8 autores
- Lisa Ceglia🇺🇸 · autor de correspondenciaTufts Medical Center
- Sathit Niramitmahapanya🇺🇸🇹🇭Tufts Medical Center; Rajavithi Hospital; Rangsit University
- Mauricio da Silva Morais🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Donato Americo Rivas🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Susan S. Harris🇺🇸Tufts Medical Center
- Heike Annette Bischoff-Ferrari🇺🇸🇨🇭Tufts Medical Center; University of Zurich; University Hospital Zurich; Stadtspital Waid
- Roger A. Fielding🇺🇸Tufts University; Jean Mayer Human Nutrition Research Center on Aging
- Bess Dawson‐Hughes🇺🇸Tufts Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Studies examining whether vitamin D supplementation increases muscle mass or muscle-specific vitamin D receptor (VDR) concentration are lacking.
Objective
Our objective was to determine whether vitamin D₃ 4000 IU/d alters muscle fiber cross-sectional area (FCSA) and intramyonuclear VDR concentration over 4 months.
Design and setting
This was a randomized, double-blind, placebo-controlled study in a single center.
Participants
Participants were 21 mobility-limited women (aged ≥ 65 years) with serum 25-hydroxyvitamin D (25OHD) levels of 22.5 to 60 nmol/L.
Main outcome measures
Baseline and 4-month FCSA and intramyonuclear VDR were measured from vastus lateralis muscle cross-sections probed for muscle fiber type (I/IIa/IIx) and VDR using immunofluorescence.
Results
At baseline, mean (±SD) age was 78 ± 5 years; body mass index was 27 ± 5 kg/m², 25OHD was 46.3 ± 9.5 nmol/L, and a short physical performance battery score was 7.95 ± 1.57 out of 12. At 4 months, 25OHD level was 52.5 ± 17.1 (placebo) vs 80.0 ± 11.5 nmol/L (vitamin D [VD]; P < .01), and change in 25OHD level was strongly associated with percent change in intramyonuclear VDR concentration-independent of group (r = 0.87, P < .001). By treatment group, percent change in intramyonuclear VDR concentration was 7.8% ± 18.2% (placebo) vs 29.7% ± 11.7% (VD; P = .03) with a more pronounced group difference in type II vs I fibers. Percent change in total (type I/II) FCSA was -7.4% ± 18.9% (placebo) vs 10.6% ± 20.0% (VD; P = .048).
Conclusion
Vitamin D₃ supplementation increased intramyonuclear VDR concentration by 30% and increased muscle fiber size by 10% in older, mobility-limited, vitamin D-insufficient women. Further work is needed to determine whether the observed effect of vitamin D on fiber size is mediated by the VDR and to identify which signaling pathways are involved.
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