Nut consumption and risk of pancreatic cancer in women
Bao Y, Hu FB, Giovannucci EL, Wolpin BM, Stampfer MJ, Willett WC, Fuchs CS
British journal of cancer · 35 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Brigham and Women's Hospital
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (U54CA155626); National Cancer Institute (K07-CA140790); National Cancer Institute (1U54 CA155626-01); National Cancer Institute (P01 CA087969); National Institute of Diabetes and Digestive and Kidney Diseases (T-32 DK 007703); National Cancer Institute (R01CA124908); National Institutes of Health (1u54ca155626-01); National Cancer Institute ([P01 CA87969); National Institutes of Health (P01 CA 87969); National Institutes of Health (R01 CA124908); National Institutes of Health (1U54CA155626); National Institutes of Health (CA 87969)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2013-10-22 · Br J Cancer · vol. 109 · número 11 · págs. 2911–2916
- Editorial
- Springer Nature
- Citado
- 62 citas · más que el 93% de estudios similares · 3.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-SA
- Áreas de investigación
- Nuts composition and effects · Oral Health Pathology and Treatment · Botany, Ecology, and Taxonomy Studies
- Palabras clave
- Medicine, Pancreatic cancer, Body mass index, Prospective cohort study, Relative risk, Diabetes mellitus, Risk factor, Cancer, Confidence interval, Internal medicine, Cohort study, Nut, Proportional hazards model, Cohort, Surgery, Endocrinology
- MeSH
- humans, nuts, pancreatic neoplasms, diet surveys, risk factors, feeding behavior, eating, adult, aged, middle aged, united states, female, surveys and questionnaires
7 autores
- Ying Bao🇺🇸 · autor de correspondenciaBrigham and Women's Hospital; Harvard University
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
- Brian Matthew Wolpin🇺🇸Brigham and Women's Hospital; Harvard University; Dana-Farber Cancer Institute
- Meir J. Stampfer🇺🇸Brigham and Women's Hospital; Harvard University
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Charles S. Fuchs🇺🇸Brigham and Women's Hospital; Harvard University; Dana-Farber Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Increasing nut intake has been associated with reduced risk of diabetes mellitus, which is a risk factor for pancreatic cancer.
Methods
We prospectively followed 75 680 women in the Nurses' Health Study, and examined the association between nut consumption and pancreatic cancer risk. Participants with a previous history of cancer were excluded. Nut consumption was assessed at baseline and updated every 2 to 4 years. Relative risks (RRs) and 95% confidence intervals (95% CIs) were estimated using Cox proportional hazards models.
Results
We documented 466 incident cases of pancreatic cancer. After adjusting for age, height, smoking, physical activity, and total energy intake, women who consumed a 28-g (1 oz) serving size of nuts ≥2 times per week experienced a significantly lower risk of pancreatic cancer (RR, 0.65; 95% CI, 0.47-0.92; P for trend=0.007) when compared with those who largely abstained from nuts. The results did not appreciably change after further adjustment for body mass index (BMI) and history of diabetes mellitus (RR, 0.68; 95% CI, 0.48-0.95; P for trend=0.01). The inverse association persisted within strata defined by BMI, physical activity, smoking, and intakes of red meat, fruits, and vegetables.
Conclusion
Frequent nut consumption is inversely associated with risk of pancreatic cancer in this large prospective cohort of women, independent of other potential risk factors for pancreatic cancer.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC-SA).
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