Whole grain and refined grain consumption and the risk of type 2 diabetes: a systematic review and dose-response meta-analysis of cohort studies
Aune D, Norat T, Romundstad P, Vatten LJ
European journal of epidemiology · 374 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Norges Teknisk-Naturvitenskapelige Universitet
- Gobierno
- Helse Midt-Norge
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-10-24 · Eur J Epidemiol · vol. 28 · número 11 · págs. 845–858
- Editorial
- Springer Science+Business Media
- Citado
- 539 citas · más que el 98% de estudios similares · 4.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 70 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Nutritional Studies and Diet · Diabetes, Cardiovascular Risks, and Lipoproteins
- Palabras clave
- whole grain intake, refined grains, type 2 diabetes, dose-response relationship, white rice, whole grain bread, whole grain cereals, wheat bran, brown rice, dietary risk factors
- MeSH
- humans, diabetes mellitus, type 2, dietary carbohydrates, diet, risk, dietary fiber, oryza, edible grain
4 autores
- Dagfinn Aune🇳🇴 · autor de correspondenciaNorwegian University of Science and Technology
- Teresa Norat🇬🇧Imperial College London
- Pål Romundstad🇳🇴Norwegian University of Science and Technology
- LARS JOHAN VATTEN🇳🇴Norwegian University of Science and Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Several studies have suggested a protective effect of intake of whole grains, but not refined grains on type 2 diabetes risk, but the dose-response relationship between different types of grains and type 2 diabetes has not been established. We conducted a systematic review and meta-analysis of prospective studies of grain intake and type 2 diabetes. We searched the PubMed database for studies of grain intake and risk of type 2 diabetes, up to June 5th, 2013. Summary relative risks were calculated using a random effects model. Sixteen cohort studies were included in the analyses. The summary relative risk per 3 servings per day was 0.68 (95% CI 0.58-0.81, I(2) = 82%, n = 10) for whole grains and 0.95 (95% CI 0.88-1.04, I(2) = 53%, n = 6) for refined grains. A nonlinear association was observed for whole grains, p nonlinearity < 0.0001, but not for refined grains, p nonlinearity = 0.10. Inverse associations were observed for subtypes of whole grains including whole grain bread, whole grain cereals, wheat bran and brown rice, but these results were based on few studies, while white rice was associated with increased risk. Our meta-analysis suggests that a high whole grain intake, but not refined grains, is associated with reduced type 2 diabetes risk. However, a positive association with intake of white rice and inverse associations between several specific types of whole grains and type 2 diabetes warrant further investigations. Our results support public health recommendations to replace refined grains with whole grains and suggest that at least two servings of whole grains per day should be consumed to reduce type 2 diabetes risk.
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