Maternal vitamin D status during pregnancy and bone mass in offspring at 20 years of age: a prospective cohort study
Zhu K, Whitehouse AJ, Hart PH, Kusel M, Mountain J, Lye S, Pennell C, Walsh JP
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 100 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Organización sin fines de lucro
- Raine Medical Research Foundation
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- National Health and Medical Research Council
Según 3 financiadores declarados.
Publicación
- Publicado
- 2013-11-05 · J Bone Miner Res · vol. 29 · número 5 · págs. 1088–1095
- Editorial
- Oxford University Press
- Citado
- 137 citas · más que el 98% de estudios similares · 8.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio) · OTHER-OA
- Áreas de investigación
- Vitamin D Research Studies · Bone health and osteoporosis research · Birth, Development, and Health
- Palabras clave
- maternal vitamin D status, vitamin D deficiency in pregnancy, 25-hydroxyvitamin D, peak bone mass, bone mineral content, bone mineral density, skeletal maturity, fracture risk, prenatal nutrition
- MeSH
- humans, prenatal exposure delayed effects, vitamin d deficiency, vitamin d, follow-up studies, prospective studies, adult children, pregnancy, pregnancy trimester, second, bone density, adult, female, male
8 autores
- Kun Zhu🇦🇺 · autor de correspondenciaThe University of Western Australia; Sir Charles Gairdner Hospital
- Andrew Whitehouse🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Prue H. Hart🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Merci M.H. Kusel🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Jenny Mountain🇦🇺The Kids Research Institute Australia; The University of Western Australia
- Stephen James Lye🇨🇦Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute
- Craig Edward Pennell🇦🇺The University of Western Australia
- John P. Walsh🇦🇺The University of Western Australia; Sir Charles Gairdner Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
It is uncertain whether the vitamin D status of pregnant women influences bone mass of their children. Cohort studies have yielded conflicting results; none have examined offspring at skeletal maturity. This longitudinal, prospective study investigated the association between maternal vitamin D status and peak bone mass of offspring in 341 mother and offspring pairs in the Western Australian Pregnancy Cohort (Raine) Study. Maternal serum samples collected at 18 weeks gestation were assayed for 25-hydroxyvitamin D (25OHD). Outcomes were total body bone mineral content (BMC) and bone mineral density (BMD) measured by dual-energy X-ray absorptiometry in offspring at 20 years of age. The mean (± SD) maternal serum 25OHD concentration was 57.2 ± 19.2 nmol/L; 132 women (38.7%) were vitamin D-deficient (25OHD <50 nmol/L). After adjustment for season of sample collection, maternal factors, and offspring factors (sex, birth weight, and age, height, lean mass, and fat mass at 20 years), maternal 25OHD concentration was positively associated with total body BMC and BMD in offspring, with a mean difference of 19.2 (95% confidence interval [CI], 5.6-32.7) g for BMC and 4.6 (95% CI, 0.1-9.1) mg/cm(2) for BMD per 10.0 nmol/L of maternal 25OHD. Maternal vitamin D deficiency was associated with 2.7% lower total body BMC (mean ± SE) (2846 ± 20 versus 2924 ± 16 g, p = 0.004) and 1.7% lower total body BMD (1053 ± 7 versus 1071 ± 5 mg/cm(2) , p = 0.043) in the offspring. We conclude that vitamin D deficiency in pregnant women is associated with lower peak bone mass in their children. This may increase fracture risk in the offspring in later life.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.