Plasma alkylresorcinol metabolites as biomarkers for whole-grain intake and their association with prostate cancer: a Swedish nested case-control study
Drake I, Sonestedt E, Gullberg B, Bjartell A, Olsson H, Adlercreutz H, Tikkanen MJ, Wirfält E, Wallström P
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology · 14 citas
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- Lunds Universitet
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-11-12 · Cancer Epidemiol Biomarkers Prev · vol. 23 · número 1 · págs. 73–83
- Editorial
- American Association for Cancer Research
- Citado
- 26 citas · más que el 74% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Food composition and properties · Phytoestrogen effects and research · Colorectal Cancer Screening and Detection
- Palabras clave
- Prostate cancer, Confounding, Nested case-control study, Metabolite, Internal medicine, Case-control study, Confidence interval, Medicine, Cancer, Odds ratio, Logistic regression, Oncology, Physiology, Endocrinology
- MeSH
- humans, prostatic neoplasms, resorcinols, diet, logistic models, case-control studies, cohort studies, prospective studies, dietary fiber, aged, middle aged, sweden, male, surveys and questionnaires, edible grain, biomarkers, tumor
9 autores
- Isabel Drake🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Emily Sonestedt🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Bo Gullberg🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Anders S Bjartell🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Hakan Lars Olsson🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Herman Adlercreutz🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Matti J. Tikkanen🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Elisabet Wirfält🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
- Peter Wallström🇫🇮🇸🇪University of Helsinki; Lund University; Skåne University Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Observational studies have mostly found no association between self-reported whole-grain intake and prostate cancer. Plasma alkylresorcinol metabolites have been suggested as biomarkers for whole-grain intake in free-living populations.
Methods
We investigated the major dietary and lifestyle determinants of plasma alkylresorcinol metabolites in a nested case-control study (1,016 cases and 1,817 controls) in the Malmö Diet and Cancer Study. Multivariate adjusted ORs and 95% confidence intervals (95% CI) were estimated to assess the association between plasma alkylresorcinol metabolites and prostate cancer using logistic regression.
Results
Whole-grain intake, waist circumference, educational level, and smoking status were the main determinants of alkylresorcinol metabolites. We observed significant correlations between alkylresorcinol metabolites and whole-grain (r = 0.31) and fiber (r = 0.27) intake. Metabolite concentration was positively associated with prostate cancer risk (Poverall effect = 0.0004) but the association was not linear (P = 0.04). The lowest risk was seen among men with moderate plasma concentrations. The OR for high compared with moderate plasma alkylresorcinol metabolites was 1.41 (95% CI, 1.10-1.80) for prostate cancer.
Conclusions
Results suggest that plasma alkylresorcinol metabolites are mainly determined by whole-grain intake in this nested case-control study of Swedish men. The increased risk of prostate cancer seen among men with high plasma alkylresorcinol metabolites requires further study, but residual confounding, detection bias, or competing risks of nonprostate cancer-related deaths are plausible explanations that could not be ruled out.
Impact
We found no evidence of a protective effect of whole grains on incident prostate cancer. Further validation of alkylresorcinol metabolites as a biomarker for whole-grain intake is needed.
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