The effect of caffeine on tear secretion
Osei KA, Ovenseri-Ogbomo G, Kyei S, Ntodie M
Optometry and vision science : official publication of the American Academy of Optometry · 25 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-11-15 · Optom Vis Sci · vol. 91 · número 2 · págs. 171–177
- Editorial
- Lippincott Williams & Wilkins
- Citado
- 39 citas · más que el 84% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Ocular Surface and Contact Lens · Coffee research and impacts · Salivary Gland Disorders and Functions
- Palabras clave
- caffeine, tear secretion, Schirmer test, tear film, dry eye, healthy volunteers
- MeSH
- lacrimal apparatus, tears, humans, caffeine, central nervous system stimulants, cross-over studies, double-blind method, adult, female, male, young adult, healthy volunteers
4 autores
- Kwaku A. Osei🇬🇭 · autor de correspondenciaUniversity of Cape Coast
- Godwin O. Ovenseri-Ogbomo🇬🇭🇳🇬University of Cape Coast; University of Benin
- Samuel Kyei🇬🇭University of Cape Coast
- Michael Ntodie🇬🇭🇺🇸 · autor de correspondenciaUniversity of Cape Coast; Office of the Director
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
Caffeine, probably the most widely consumed psychoactive substance, is claimed to have conflicting effects on some tear film dynamics. This study sought to investigate the effect of orally ingested caffeine on tear secretion.
Methods
In an examiner-masked, placebo-controlled, crossover experimental model, the effect of caffeine intake on tear secretion was studied in 41 healthy volunteers aged 20 to 26 years (mean, 23.0 ± 2.1 years). Participants were randomly assigned into two groups, A and B, to receive two different treatments in two sessions. Subjects in group A were exposed to 5.0 mg/kg body weight of caffeine dissolved in 200 mL of water on their first visit, whereas those in group B were exposed to 200 mL of water. On the second visit, however, the order of treatment was reversed. Schirmer 1 scores were measured repeatedly at 45, 90, 135, and 180 minutes after treatment. The baseline Schirmer 1 scores were compared with posttreatment scores.
Results
Schirmer 1 scores increased after caffeine intake. The increase was statistically significant at 45 and 90 minutes (p 0.05). There was no influence of gender in caffeine's effect on tear secretion (F = 0.994, p = 0.399).
Conclusions
From our study, orally ingested caffeine appears to stimulate tear secretion in healthy non-dry eye subjects.
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