Dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study
Dellavalle CT, Xiao Q, Yang G, Shu XO, Aschebrook-Kilfoy B, Zheng W, Zheng W, Lan Li H, Ji BT, Rothman N, Chow WH, Gao YT, Ward MH
International journal of cancer · 76 citas
Etiquetas de revisión
Cuestionario de frecuencia de consumoSin ajuste declarado por estilo de vidaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- Cuestionario de frecuencia de consumo
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institutes of Health
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Gobierno
- Intramural NIH HHS
- Subvenciones
- National Cancer Institute (N02-CP-11010-66); National Cancer Institute (UM1 CA182910); National Cancer Institute (R37-CA070867); National Institutes of Health (N02 CP1101066); National Cancer Institute (R37-CA70867); National Institutes of Health (Z01 CP010153); National Institutes of Health (R37CA70867)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-11-15 · Int J Cancer · vol. 134 · número 12 · págs. 2917–2926
- Editorial
- Wiley
- Citado
- 126 citas · más que el 98% de estudios similares · 9.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nutritional Studies and Diet · Sodium Intake and Health · Sulfur Compounds in Biology
- Palabras clave
- Medicine, Hazard ratio, Colorectal cancer, Nitrite, Nitrate, Proportional hazards model, Vitamin, Internal medicine, Vitamin C, Cancer, Physiology, Prospective cohort study, Lower risk, Confidence interval, Gastroenterology, Biology
- MeSH
- humans, colorectal neoplasms, cell transformation, neoplastic, nitrates, nitrites, ascorbic acid, nitroso compounds, diet, risk, prospective studies, feeding behavior, meat, adult, aged, middle aged, women's health, china, female, surveys and questionnaires
12 autores
- Curt T. DellaValle🇺🇸National Institutes of Health; National Cancer Institute
- Qian Xun Xiao🇺🇸National Institutes of Health; National Cancer Institute
- Gong Yang🇺🇸Vanderbilt University
- Xiao‐Ou Shu🇺🇸Vanderbilt University
- Briseis Aschebrook‐Kilfoy🇺🇸University of Chicago
- Wei Zheng🇺🇸Vanderbilt University
- Hong Lan Li🇨🇳Shanghai Cancer Institute
- Bu‐Tian Ji🇺🇸National Institutes of Health; National Cancer Institute
- Nathaniel Rothman🇺🇸National Institutes of Health; National Cancer Institute
- Wong‐Ho Chow🇺🇸The University of Texas MD Anderson Cancer Center
- Yu‐Tang Gao🇨🇳Shanghai Cancer Institute
- Mary H. Ward🇺🇸 · autor de correspondenciaNational Institutes of Health; National Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Nitrate and nitrite are precursors of endogenously formed N-nitroso compounds (NOC), known animal carcinogens. Nitrosation reactions forming NOCs can be inhibited by vitamin C and other antioxidants. We prospectively investigated the association between dietary nitrate and nitrite intake and risk of colorectal cancer in the Shanghai Women's Health Study, a cohort of 73,118 women ages 40-70 residing in Shanghai. We evaluated effect modification by factors that affect endogenous formation of NOCs: vitamin C (at or above/below median) and red meat intake (at or above/below median). Nitrate, nitrite and other dietary intakes were estimated from a 77-item food frequency questionnaire administered at baseline. Over a mean of 11 years of follow-up, we identified 619 colorectal cancer cases (n = 383, colon; n = 236, rectum). Hazard ratios (HR) and 95% confidence intervals (CI) were estimated using Cox proportional hazard regression. Overall, nitrate intake was not associated with colorectal cancer risk (HR = 1.08; 95% CI: 0.73-1.59). However, among women with vitamin C intake below the median (83.9 mg day(-1) ) and hence higher potential exposure to NOCs, risk of colorectal cancer increased with increasing quintiles of nitrate intake (highest vs. lowest quintile HR = 2.45; 95% CI: 1.15-5.18; p trend = 0.02). There was no association among women with higher vitamin C intake. We found no association between nitrite intake and risk of colorectal cancer overall or by intake level of vitamin C. Our findings suggest that high dietary nitrate intake among subgroups expected to have higher exposure to endogenously formed NOCs increases risk of colorectal cancer.
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