Chemopreventive and therapeutic activity of dietary blueberry against estrogen-mediated breast cancer
Jeyabalan J, Aqil F, Munagala R, Annamalai L, Vadhanam MV, Gupta RC
Journal of agricultural and food chemistry · 55 citas
Cómo se estudió
- Diseño
- Estudio en animales (clasificado por nuestro filtro de IA)
- Estudiado en
- Animales
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Cancer Institute
- Gobierno
- NCI NIH HHS
- Subvenciones
- National Cancer Institute (CA-125152); National Cancer Institute (CA-118114)
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-11-18 · J Agric Food Chem · vol. 62 · número 18 · págs. 3963–3971
- Editorial
- American Chemical Society
- Citado
- 80 citas · más que el 81% de estudios similares · 1.6× el promedio de su campo
- Referencias
- 49 trabajos
- Acceso
- Acceso abierto (revista híbrida) · OTHER-OA
- Áreas de investigación
- Phytochemicals and Antioxidant Activities · Bioactive Compounds in Plants · Garlic and Onion Studies
- Palabras clave
- Carcinogenesis, Estrogen, Breast cancer, Therapeutic effect, Medicine, Mammary tumor, Internal medicine, Cancer research, Mammary gland, Oncology, Cancer, Endocrinology, Physiology
- MeSH
- animals, rats, inbred aci, humans, rats, fruit, breast neoplasms, estradiol, cytochrome p-450 cyp1a1, estrogen receptor alpha, micrornas, estrogens, female, blueberry plants
6 autores
- Jeyaprakash Jeyabalan🇺🇸University of Louisville; University of Louisville Hospital
- Farrukh Aqil🇺🇸University of Louisville; University of Louisville Hospital
- Radha Munagala🇺🇸University of Louisville; University of Louisville Hospital
- Lakshmanan Annamalai🇺🇸University of Louisville; University of Louisville Hospital
- Manicka V. Vadhanam🇺🇸University of Louisville; University of Louisville Hospital
- Ramesh Chand Gupta🇺🇸 · autor de correspondenciaUniversity of Louisville; University of Louisville Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Berries are gaining increasing importance lately for their chemopreventive and therapeutic potential against several cancers. In earlier studies, a blueberry-supplemented diet has shown protection against 17β-estradiol (E2)-mediated mammary tumorigenesis. This study tested both preventive and therapeutic activities of diet supplemented with whole blueberry powder (50:50 blend of Tifblue and Rubel). Animals received 5% blueberry diet, either 2 weeks prior to or 12 weeks after E2 treatment in preventive and therapeutic groups, respectively. Both interventions delayed the tumor latency for palpable mammary tumors by 28 and 37 days, respectively. Tumor volume and multiplicity were also reduced significantly in both modes. The effect on mammary tumorigenesis was largely due to down-regulation of CYP 1A1 and ER-α gene expression and also favorable modulation of microRNA (miR-18a and miR-34c) levels. These data suggest that the blueberry blend tested is effective in inhibiting E2-mediated mammary tumorigenesis in both preventive and therapeutic modes.
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