Large, single-dose, oral vitamin D supplementation in adult populations: a systematic review
Kearns MD, Alvarez JA, Tangpricha V
Endocrine practice : official journal of the American College of Endocrinology and the American Association of Clinical Endocrinologists · 98 citas
Cómo se estudió
- Diseño
- Revisión sistemática (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- National Center for Advancing Translational Sciences
- Gobierno
- NCATS NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Center for Advancing Translational Sciences (UL1 TR000454); National Institute of Diabetes and Digestive and Kidney Diseases (T32DK007298)
Según 4 financiadores declarados.
Publicación
- Publicado
- 2013-11-18 · Endocr Pract · vol. 20 · número 4 · págs. 341–351
- Editorial
- Elsevier BV
- Citado
- 136 citas · más que el 67% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Parathyroid Disorders and Treatments · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, vitamin D deficiency, vitamin D3, vitamin D2, 25-hydroxyvitamin D, parathyroid hormone, bone health, adults
- MeSH
- humans, parathyroid hormone, vitamin d, administration, oral, dietary supplements, adult
3 autores
- Malcolm D. Kearns🇺🇸Emory University
- Jessica A. Alvarez🇺🇸Emory University
- Vin Tangpricha🇺🇸 · autor de correspondenciaEmory University; Atlanta VA Medical Center
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
Daily vitamin D supplementation is often inadequate in treating vitamin D deficiency due to poor compliance. A single, large dose of vitamin D given at timed intervals may be an alternative strategy.
Methods
We conducted a systematic literature review to investigate the efficacy of a single large bolus dose to treat vitamin D deficiency. We identified 2,243 articles in PubMed using the terms "high dose vitamin D," "single dose vitamin D," "bolus vitamin D," or "annual dose vitamin D." Review articles, cross-sectional studies, non-human studies, responses to other articles, and non-English articles were excluded. Manuscripts were also excluded if the study: (1) did not use oral cholecalciferol or ergocalciferol, (2) used vitamin D analogs, (3) enrolled participants under age 18 years, (4) administered doses 1 dose per year. References of eligible manuscripts and the Cochrane databases were also searched. Two independent reviewers identified eligible manuscripts, and a third reviewer evaluated disagreements. Thirty manuscripts were selected using these criteria.
Results
Large, single doses of vitamin D consistently increased serum/plasma 25-hydroxyvitamin D (25[OH]D) concentrations in several vitamin D-sufficient and -deficient populations. Vitamin D3 doses ≥300,000 IU provided optimal changes in serum/plasma 25(OH)D and parathyroid hormone (PTH) concentrations. Vitamin D supplementation also impacted bone health and extraskeletal endpoints.
Conclusion
This review recommends that vitamin D3 be used for supplementation over vitamin D2 and concludes that single vitamin D3 doses ≥300,000 IU are most effective at improving vitamin D status and suppressing PTH concentrations for up to 3 months. Lower doses, however, may be sufficient in certain populations. Vitamin D doses >500,000 IU should be used judiciously in order to minimize adverse events.
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