Determinants of erythrocyte omega-3 fatty acid content in response to fish oil supplementation: a dose-response randomized controlled trial
Flock MR, Skulas-Ray AC, Harris WS, Etherton TD, Fleming JA, Kris-Etherton PM
Journal of the American Heart Association · 185 citas
Etiquetas de revisión
Vínculos de autores con la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Posiblemente financiado por la industria
- Gobierno
- U.S. Department of Agriculture
- Gobierno
- Cooperative State Research, Education, and Extension Service
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 2 financiadores declarados y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-11-18 · J Am Heart Assoc · vol. 2 · número 6 · pág. e000513
- Editorial
- Wiley
- Citado
- 223 citas · más que el 99% de estudios similares · 15.5× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 52 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Fatty Acid Research and Health · Aquaculture Nutrition and Growth · Nutritional Studies and Diet
- Palabras clave
- omega-3 index, erythrocyte membrane fatty acids, eicosapentaenoic acid, docosahexaenoic acid, fish oil supplementation, dose-response relationship, body weight, predictors of treatment response, cardiovascular risk
- MeSH
- erythrocytes, humans, body weight, docosahexaenoic acids, eicosapentaenoic acid, drug combinations, administration, oral, multivariate analysis, double-blind method, dose-response relationship, drug, time factors, dietary supplements, adult, middle aged, pennsylvania, female, male, drug dosage calculations, young adult, healthy volunteers
6 autores
- Michael R. Flock🇺🇸Pennsylvania State University
- Ann C. Skulas‐Ray🇺🇸Pennsylvania State University
- William Stephen Harris
- Terry D. Etherton🇺🇸Pennsylvania State University
- Jennifer A Fleming🇺🇸Pennsylvania State University
- Penny M. Kris‐Etherton🇺🇸Pennsylvania State University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
The erythrocyte membrane content of eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA), which constitutes the omega-3 index (O3I), predicts cardiovascular disease mortality. The amount of EPA+DHA needed to achieve a target O3I is poorly defined, as are the determinants of the O3I response to a change in EPA+DHA intake. The objective of this study was to develop a predictive model of the O3I response to EPA+DHA supplementation in healthy adults, specifically identifying factors that determine the response.
Methods and results
A randomized, placebo-controlled, double-blind, parallel-group study was conducted in 115 healthy men and women. One of 5 doses (0, 300, 600, 900, 1800 mg) of EPA+DHA was given daily as placebo or fish oil supplements for ≈5 months. The O3I was measured at baseline and at the end of the study. There were no significant differences in the clinical characteristics between the groups at baseline. The O3I increased in a dose-dependent manner (P<0.0001), with the dose of EPA+DHA alone accounting for 68% (quadratic, P<0.0001) of the variability in the O3I response. Dose adjusted per unit body weight (g/kg) accounted for 70% (linear, P<0.0001). Additional factors that improved prediction of treatment response were baseline O3I, age, sex, and physical activity. Collectively, these explained 78% of the response variability (P<0.0001).
Conclusions
Our findings validate the O3I as a biomarker of EPA+DHA consumption and identify additional factors, particularly body weight, that can be used to tailor EPA+DHA recommendations to achieve a target O3I.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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