Association of nut consumption with total and cause-specific mortality
Bao Y, Han J, Hu FB, Giovannucci EL, Stampfer MJ, Willett WC, Fuchs CS
The New England journal of medicine · 239 citas
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Cómo se estudió
- Diseño
- Estudio de cohortes (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Heart, Lung, and Blood Institute
- Gobierno
- National Cancer Institute
- Gobierno
- National Institute of Diabetes and Digestive and Kidney Diseases
- Gobierno
- NCI NIH HHS
- Gobierno
- NHLBI NIH HHS
- Gobierno
- NIDDK NIH HHS
- Subvenciones
- National Cancer Institute (U54CA155626); National Cancer Institute (P01 CA055075.); National Cancer Institute (1U54 CA155626-01); National Cancer Institute (P01 CA087969); National Institute of Diabetes and Digestive and Kidney Diseases (T-32 DK 007703); National Cancer Institute (R01CA124908); National Cancer Institute (UM1-CA-167552); National Cancer Institute (P50-CA127003); National Heart, Lung, and Blood Institute (R01 HL060712); National Cancer Institute ([P01 CA87969); National Heart, Lung, and Blood Institute (R01HL60712)
Según 6 financiadores declarados.
Publicación
- Publicado
- 2013-11-20 · N Engl J Med · vol. 369 · número 21 · págs. 2001–2011
- Editorial
- Massachusetts Medical Society
- Citado
- 363 citas · más que el 100% de estudios similares · 26.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 42 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Nuts composition and effects · Peanut Plant Research Studies · Botany, Ecology, and Taxonomy Studies
- Palabras clave
- Medicine, Nut, Hazard ratio, Confidence interval, Diabetes mellitus, Stroke (engine), Demography, Consumption (sociology), Internal medicine, Endocrinology
- MeSH
- humans, nuts, neoplasms, respiratory tract diseases, heart diseases, diet, diet surveys, mortality, cause of death, multivariate analysis, proportional hazards models, cohort studies, life style, aged, middle aged, female, male, surveys and questionnaires, confounding factors, epidemiologic
7 autores
- Ying Bao🇺🇸Indiana University Health; Brigham and Women's Hospital; Harvard University; Woman's Hospital; Indiana University – Purdue University Indianapolis
- Jiali Han🇺🇸Indiana University Health; Indiana University Indianapolis; Indiana University – Purdue University Indianapolis
- Frank B. Hu🇺🇸Brigham and Women's Hospital; Harvard University
- Edward L. Giovannucci🇺🇸Brigham and Women's Hospital; Harvard University
- Meir J. Stampfer🇺🇸Brigham and Women's Hospital; Harvard University
- Walter Churchill Willett🇺🇸Brigham and Women's Hospital; Harvard University
- Charles S. Fuchs🇺🇸Brigham and Women's Hospital; Harvard University; Dana-Farber Cancer Institute
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Increased nut consumption has been associated with a reduced risk of major chronic diseases, including cardiovascular disease and type 2 diabetes mellitus. However, the association between nut consumption and mortality remains unclear.
Methods
We examined the association between nut consumption and subsequent total and cause-specific mortality among 76,464 women in the Nurses' Health Study (1980-2010) and 42,498 men in the Health Professionals Follow-up Study (1986-2010). Participants with a history of cancer, heart disease, or stroke were excluded. Nut consumption was assessed at baseline and updated every 2 to 4 years.
Results
During 3,038,853 person-years of follow-up, 16,200 women and 11,229 men died. Nut consumption was inversely associated with total mortality among both women and men, after adjustment for other known or suspected risk factors. The pooled multivariate hazard ratios for death among participants who ate nuts, as compared with those who did not, were 0.93 (95% confidence interval [CI], 0.90 to 0.96) for the consumption of nuts less than once per week, 0.89 (95% CI, 0.86 to 0.93) for once per week, 0.87 (95% CI, 0.83 to 0.90) for two to four times per week, 0.85 (95% CI, 0.79 to 0.91) for five or six times per week, and 0.80 (95% CI, 0.73 to 0.86) for seven or more times per week (P<0.001 for trend). Significant inverse associations were also observed between nut consumption and deaths due to cancer, heart disease, and respiratory disease.
Conclusions
In two large, independent cohorts of nurses and other health professionals, the frequency of nut consumption was inversely associated with total and cause-specific mortality, independently of other predictors of death. (Funded by the National Institutes of Health and the International Tree Nut Council Nutrition Research and Education Foundation.).
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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