Dietary magnesium intake is inversely associated with mortality in adults at high cardiovascular disease risk
Guasch-Ferré M, Bulló M, Estruch R, Corella D, Martínez-González MA, Ros E, Covas M, Arós F, Gómez-Gracia E, Fiol M, Lapetra J, Muñoz MÁ, Serra-Majem L, Babio N, Pintó X, Lamuela-Raventós RM, Ruiz-Gutiérrez V, Salas-Salvadó J, PREDIMED Study Group
The Journal of nutrition · 47 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación independiente
- Sin clasificar
- Thematic Network
- Gobierno
- European Fund of Regional Development
- Universidad u hospital
- Institute of Catalan Studies
- Gobierno
- Spanish Ministry of Health
- Organización sin fines de lucro
- The Communal Olive Heritage Foundation
Según 5 financiadores declarados.
Publicación
- Publicado
- 2013-11-21 · J Nutr · vol. 144 · número 1 · págs. 55–60
- Editorial
- Elsevier BV
- Citado
- 77 citas · más que el 96% de estudios similares · 5.8× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 28 trabajos
- Acceso
- Lectura gratuita
- Áreas de investigación
- Magnesium in Health and Disease · Nutritional Studies and Diet · Magnesium Oxide Properties and Applications
- Palabras clave
- dietary magnesium, all-cause mortality, cardiovascular disease, cancer mortality, Mediterranean diet, PREDIMED trial, high cardiovascular risk, older adults, olive oil supplementation, nuts
- MeSH
- humans, nuts, neoplasms, cardiovascular diseases, magnesium, plant oils, diet, fat-restricted, multivariate analysis, risk factors, follow-up studies, prospective studies, diet, mediterranean, dietary supplements, aged, aged, 80 and over, middle aged, mediterranean region, female, male, olive oil
18 autores
- Marta Guasch‐Ferré🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Mònica Bulló🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Ramón Estruch🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
- Dolores Corella🇪🇸Universitat de València; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Miguel Ángel Martínez‐González🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Navarra
- Emilio Ros🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Clínic de Barcelona; Consorci Institut D'Investigacions Biomediques August Pi I Sunyer; Universitat de Barcelona
- Maribel I. Covas🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Barcelona Biomedical Research Park; Hospital Del Mar; Hospital del Mar Research Institute
- Fernando Arós🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Araba
- Enrique Gómez‐Gracia🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universidad de Málaga
- Miquel Fiol🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Hospital Universitario Son Espases; Universitat de les Illes Balears
- José Lapetra🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Miguel Ángel Muñoz🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut Universitari d'Investigació en Atenció Primària Jordi Gol
- Lluís Serra‐Majem🇪🇸Universidad de Las Palmas de Gran Canaria; Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition
- Nancy Babió🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
- Xavier Pintó🇪🇸Bellvitge University Hospital
- Rosa Maria Lamuela-Raventós🇪🇸Instituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Universitat de Barcelona
- Valentina Ruíz-Gutiérrez🇪🇸Consejo Superior de Investigaciones Científicas; Instituto de la Grasa
- Jordi Salas‐Salvadó🇪🇸 · autor de correspondenciaInstituto de Salud Carlos III; Spanish Biomedical Research Centre in Physiopathology of Obesity and Nutrition; Institut de Recerca Biomèdica Catalunya Sud; Hospital Universitari Sant Joan de Reus; Universitat Rovira i Virgili
Resumen
El texto original del estudio, en el idioma en que se publicó.
The relation between dietary magnesium intake and cardiovascular disease (CVD) or mortality was evaluated in several prospective studies, but few of them have assessed the risk of all-cause mortality, which has never been evaluated in Mediterranean adults at high cardiovascular risk. The aim of this study was to assess the association between magnesium intake and CVD and mortality risk in a Mediterranean population at high cardiovascular risk with high average magnesium intake. The present study included 7216 men and women aged 55-80 y from the PREDIMED (Prevención con Dieta Mediterránea) study, a randomized clinical trial. Participants were assigned to 1 of 2 Mediterranean diets (supplemented with nuts or olive oil) or to a control diet (advice on a low-fat diet). Mortality was ascertained by linkage to the National Death Index and medical records. We fitted multivariable-adjusted Cox regressions to assess associations between baseline energy-adjusted tertiles of magnesium intake and relative risk of CVD and mortality. Multivariable analyses with generalized estimating equation models were used to assess the associations between yearly repeated measurements of magnesium intake and mortality. After a median follow-up of 4.8 y, 323 total deaths, 81 cardiovascular deaths, 130 cancer deaths, and 277 cardiovascular events occurred. Energy-adjusted baseline magnesium intake was inversely associated with cardiovascular, cancer, and all-cause mortality. Compared with lower consumers, individuals in the highest tertile of magnesium intake had a 34% reduction in mortality risk (HR: 0.66; 95% CI: 0.45, 0.95; P < 0.01). Dietary magnesium intake was inversely associated with mortality risk in Mediterranean individuals at high risk of CVD. This trial was registered at controlled-trials.com as ISRCTN35739639.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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