Sulforaphane-rich broccoli sprout extract attenuates nasal allergic response to diesel exhaust particles
Heber D, Li Z, Garcia-Lloret M, Wong AM, Lee TY, Thames G, Krak M, Zhang Y, Nel A
Food & function · 63 citas
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Alimentación controladaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo clínico controlado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- National Institute of Allergy and Infectious Diseases
- Gobierno
- NIAID NIH HHS
- Subvenciones
- National Institute of Allergy and Infectious Diseases (U19 AI070453-01); National Institute of Allergy and Infectious Diseases (U19 AI-070453)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-11-28 · Food Funct · vol. 5 · número 1 · págs. 35–41
- Editorial
- Royal Society of Chemistry
- Citado
- 82 citas · más que el 95% de estudios similares · 4.2× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 39 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Air Quality and Health Impacts · IL-33, ST2, and ILC Pathways
- Palabras clave
- Sulforaphane, Glucoraphanin, Nasal administration, Chemistry, Oxidative stress, Pharmacology, Antioxidant, White blood cell, Inhalation, Immunology, Medicine, Biochemistry, Anesthesia, Brassica, Biology, Glucosinolate, Botany
- MeSH
- nose, humans, brassica, hypersensitivity, isothiocyanates, sulfoxides, plant extracts, air pollutants, vehicle emissions, adult, female, male, nf-e2-related factor 2
9 autores
- David Heber🇺🇸 · autor de correspondenciaUCLA Medical Center
- Zhaoping Li🇺🇸University of California, Los Angeles
- Maria Garcia-Lloret🇺🇸University of California, Los Angeles
- Angela Wong🇺🇸University of California, Los Angeles
- T. Y. Lee🇺🇸University of California, Los Angeles
- Gail Thames🇺🇸University of California, Los Angeles
- Michael D. Krak🇺🇸University of California, Los Angeles
- Yanjun Zhang🇺🇸University of California, Los Angeles
- André E. Nel🇺🇸University of California, Los Angeles
Resumen
El texto original del estudio, en el idioma en que se publicó.
The generation of oxidative stress by ambient air pollution particles contributes to the development of allergic sensitization and asthma, as demonstrated by intranasal challenge with well-characterized diesel exhaust particle (DEP) suspensions in humans. This effect is due to the presence of redox active organic chemicals in DEP, and can be suppressed by antioxidants and inducers of phase II enzymes in animals. In this communication, we determined whether the administration of a standardized broccoli sprout extract (BSE), which contains a reproducible amount of the sulforaphane (SFN) precursor, glucoraphanin, could be used to suppress the nasal inflammatory response in human subjects challenged with 300 μg of an aqueous DEP suspension (equivalent to daily PM exposure levels on a Los Angeles freeway). SFN is capable of inducing an antioxidant and phase II response via activation of the nuclear transcription factor (erythroid-derived 2)-like 2 (Nrf2). Previous studies have shown that 70-90% SFN delivered by BSE is absorbed, metabolized, and excreted in humans. An initial intranasal challenge with DEP in 29 human subjects was used to characterize the magnitude of the inflammatory response. Following a 4 week washout, a BSE that delivers a reproducible and standardized dose of 100 μmol SFN in mango juice was administered daily for four days. The nasal DEP challenge was repeated and lavage fluid collected to perform white blood cell (WBC) counts. The average nasal WBC increased by 66% over the initial screening levels and by 85% over the control levels 24 hours after DEP exposure. However, total cell counts decreased by 54% when DEP challenge was preceded by daily BSE administration for 4 days (p < 0.001). Since the SFN dose in these studies is equivalent to the consumption of 100-200 g broccoli, our study demonstrates the potential preventive and therapeutic potential of broccoli or broccoli sprouts rich in glucoraphanin for reducing the impact of particulate pollution on allergic disease and asthma.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
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