Enhanced increase of omega-3 index in healthy individuals with response to 4-week n-3 fatty acid supplementation from krill oil versus fish oil
Ramprasath VR, Eyal I, Zchut S, Jones PJ
Lipids in health and disease · 120 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Universidad u hospital
- University of Haifa
- Autores
- Al menos un autor declara un vínculo económico con la industria
Según 1 financiador declarado y la declaración de financiación del texto completo.
Publicación
- Publicado
- 2013-12-01 · Lipids Health Dis · vol. 12 · número 1 · pág. 178
- Editorial
- BioMed Central
- Citado
- 175 citas · más que el 99% de estudios similares · 12.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 53 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY
- Áreas de investigación
- Fatty Acid Research and Health · Edible Oils Quality and Analysis · Aquaculture Nutrition and Growth
- Palabras clave
- krill oil, fish oil, omega-3 index, omega-3 fatty acids, EPA, docosahexaenoic acid, n-6/n-3 ratio, plasma fatty acid profile, cholesterol, serum triglycerides, cardiovascular risk, dietary supplementation
- MeSH
- animals, humans, euphausiacea, dietary fats, unsaturated, corn oil, docosahexaenoic acids, eicosapentaenoic acid, triglycerides, fish oils, cross-over studies, double-blind method, adult, female, male, cholesterol, hdl, healthy volunteers
4 autores
- Vanu Ramkumar Ramprasath🇨🇦University of Manitoba
- Inbal Eyal🇮🇱Tower Semiconductor (Israel); MeMed (Israel); Ministry of Economy
- Sigalit Zchut🇮🇱Tower Semiconductor (Israel); MeMed (Israel); Ministry of Economy
- Peter J.H. Jones🇨🇦 · autor de correspondenciaUniversity of Manitoba
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Due to structural differences, bioavailability of krill oil, a phospholipid based oil, could be higher than fish oil, a triglyceride-based oil, conferring properties that render it more effective than fish oil in increasing omega-3 index and thereby, reducing cardiovascular disease (CVD) risk.
Objective
The objective was to assess the effects of krill oil compared with fish oil or a placebo control on plasma and red blood cell (RBC) fatty acid profile in healthy volunteers.
Participants and methods
Twenty four healthy volunteers were recruited for a double blinded, randomized, placebo-controlled, crossover trial. The study consisted of three treatment phases including krill or fish oil each providing 600 mg of n-3 polyunsaturated fatty acids (PUFA) or placebo control, corn oil in capsule form. Each treatment lasted 4 wk and was separated by 8 wk washout phases.
Results
Krill oil consumption increased plasma (p = 0.0043) and RBC (p = 0.0011) n-3 PUFA concentrations, including EPA and DHA, and reduced n-6:n-3 PUFA ratios (plasma: p = 0.0043, RBC: p = 0.0143) compared with fish oil consumption. Sum of EPA and DHA concentrations in RBC, the omega-3 index, was increased following krill oil supplementation compared with fish oil (p = 0.0143) and control (p < 0.0001). Serum triglycerides and HDL cholesterol concentrations did not change with any of the treatments. However, total and LDL cholesterol concentrations were increased following krill (TC: p = 0.0067, LDL: p = 0.0143) and fish oil supplementation (TC: p = 0.0028, LDL: p = 0.0143) compared with control.
Conclusions
Consumption of krill oil was well tolerated with no adverse events. Results indicate that krill oil could be more effective than fish oil in increasing n-3 PUFA, reducing n-6:n-3 PUFA ratio, and improving the omega-3 index.
Trial registration
ClinicalTrials.gov, NCT01323036.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY).
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