The influence of fish-oil lipid emulsions on retinopathy of prematurity in very low birth weight infants: a randomized controlled trial
Beken S, Dilli D, Fettah ND, Kabataş EU, Zenciroğlu A, Okumuş N
Early human development · 95 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-12-04 · Early Hum Dev · vol. 90 · número 1 · págs. 27–31
- Editorial
- Elsevier BV
- Citado
- 128 citas · más que el 97% de estudios similares · 6.4× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 25 trabajos
- Acceso
- De pago
- Áreas de investigación
- Retinopathy of Prematurity Studies · Infant Nutrition and Health · Clinical Nutrition and Gastroenterology
- Palabras clave
- retinopathy of prematurity, fish oil lipid emulsion, very low birth weight infants, parenteral nutrition, Intralipid, laser photocoagulation, omega-3 fatty acids
- MeSH
- humans, retinopathy of prematurity, soybean oil, fish oils, emulsions, single-blind method, adult, infant, newborn, infant, low birth weight, female, male
6 autores
- Serdar Beken🇹🇷 · autor de correspondenciaDr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
- Dílek Díllí🇹🇷Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
- Nurdan Dinlen Fettah🇹🇷Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
- Emrah Utku Kabataş🇹🇷Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
- Ayşegül Zenciroğlu🇹🇷Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
- Nurullah Okumuş🇹🇷Dr Sami Ulus Çocuk Sağlığı ve Hastalıkları Eğitim ve Araştırma Hastanesi
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To compare the effect of two lipid emulsions on the development of retinopathy of prematurity in very low birth weight infants.
Design
Randomized controlled study.
Patients and methods
Eighty very low birth weight infants receiving parenteral nutrition from the first day of life were evaluated. One of the two lipid emulsions were used in the study infants: Group 1 (n=40) received fish-oil based lipid emulsion (SmofLipid®) and Group 2 (n=40) soybean oil based lipid emulsion (Intralipid®).
Main outcome measures
The development of retinopathy of prematurity and the need for laser photocoagulation were assessed.
Results
The maternal and perinatal characteristics were similar in both groups. The median (range) duration of parenteral nutrition [14days (10-28) vs 14 (10-21)] and hospitalization [34days (20-64) vs 34 (21-53)] did not differ between the groups. Laboratory data including complete blood count, triglyceride level, liver and kidney function tests recorded before and after parenteral nutrition also did not differ between the two groups. In Group 1, two patients (5.0%) and in Group 2, 13 patients (32.5%) were diagnosed with retinopathy of prematurity (OR: 9.1, 95% CI 1.9-43.8, p=0.004). One patient in each group needed laser photocoagulation, without significant difference. Multivariate analysis showed that only receiving fish-oil emulsion in parenteral nutrition decreased the risk of development of retinopathy of prematurity [OR: 0.76, 95% CI (0.06-0.911), p=0.04].
Conclusions
Premature infants with very low birth weight receiving an intravenous fat emulsion containing fish oil developed less retinopathy of prematurity.
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