Short-term creatine supplementation does not reduce increased homocysteine concentration induced by acute exercise in humans
Deminice R, Rosa FT, Franco GS, da Cunha SF, de Freitas EC, Jordao AA
European journal of nutrition · 13 citas
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Conselho Nacional de Desenvolvimento Científico e Tecnológico
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-12-07 · Eur J Nutr · vol. 53 · número 6 · págs. 1355–1361
- Editorial
- Springer Science+Business Media
- Citado
- 20 citas · más que el 80% de estudios similares · 1.5× el promedio de su campo
- Referencias
- 40 trabajos
- Acceso
- De pago
- Áreas de investigación
- Muscle metabolism and nutrition · Exercise and Physiological Responses · Folate and B Vitamins Research
- Palabras clave
- creatine supplementation, homocysteine, acute exercise, S-adenosylmethionine, S-adenosylhomocysteine, guanidinoacetic acid, plasma creatine, vitamin B12, folic acid, methionine, cysteine, soccer players
- MeSH
- humans, creatine, cysteine, vitamin b 12, folic acid, methionine, homocysteine, s-adenosylmethionine, glycine, exercise, double-blind method, feeding behavior, energy intake, soccer, dietary supplements, adolescent, male, healthy volunteers
6 autores
- Rafael Deminice🇧🇷 · autor de correspondenciaUniversidade Estadual de Londrina; Universidade de São Paulo
- Flávia Troncon Rosa🇧🇷Universidade de São Paulo
- Gabriel Silveira Franco🇧🇷Universidade de São Paulo
- Selma Freire de Carvalho da Cunha🇧🇷Universidade de São Paulo
- Ellen Cristini de Freitas🇧🇷Universidade de São Paulo
- Alceu Afonso Jordão🇧🇷Universidade de São Paulo
Resumen
El texto original del estudio, en el idioma en que se publicó.
Purpose
The purpose of the study is to evaluate the effects of creatine supplementation on homocysteine (Hcy) plasma levels after acute exercise in humans.
Methods
Twenty-three young (under-20) soccer players were divided into 2 groups: creatine (Cr)- and placebo (Pla)-supplemented groups. The supplementation was performed in double-blind controlled manner using creatine or placebo tablets with 0.3 g/kg during 7 days. Before and after 7 days of supplementation, the athletes performed an acute high-intensity sprint exercise (two consecutive running-based anaerobic sprint test protocol consisted in 6 × 35 m sprint with 10 s between them). Blood samples were collected before and after 7 days of supplementation as well as 0 and 1 h after exercise protocol.
Results
Homocysteine concentration significant increased (P < 0.05) 1 h after acute exercise (18%). Acute exercise also decreased red blood cell S-adenosylmethionine (SAM) 30% with no changes in SAM/SAH ratio. Seven days of creatine supplementation were able to increase (P < 0.05) plasma creatine concentration (Pla 130.1 ± 21.7 vs Cr 1,557.2 ± 220.3 μmol/L) as well as decrease (P < 0.05) plasma guanidinoacetic acid (33%). Controversially, creatine supplementation did not change Hcy plasma level after 7-day supplementation (Pla 6.9 ± 0.2 vs Cr 7.2 ± 0.2 μmol/L) or after acute exercise (Pla 8.2 ± 0.3 vs Cr 8.4 ± 0.3 μmol/L). No changes in plasma vitamin B12 and folate as well as cysteine and methionine were found.
Conclusions
Seven days of creatine supplementation does not avoid increased plasma Hcy induced by acute sprint exercise in humans.
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