Cruciferous vegetables and risk of colorectal neoplasms: a systematic review and meta-analysis
Tse G, Eslick GD
Nutrition and cancer · 88 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Eventos clínicos como enfermedad o muerte
- Consumo medido con
- No se indica
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-12-16 · Nutr Cancer · vol. 66 · número 1 · págs. 128–139
- Editorial
- Routledge
- Citado
- 134 citas · más que el 68% de estudios similares · 0.9× el promedio de su campo
- Referencias
- 60 trabajos
- Acceso
- De pago
- Áreas de investigación
- Genomics, phytochemicals, and oxidative stress · Glutathione Transferases and Polymorphisms · Nitrogen and Sulfur Effects on Brassica
- Palabras clave
- Cruciferous vegetables, Colorectal cancer, Confidence interval, Medicine, Odds ratio, Meta-analysis, Genotype, Internal medicine, Biology, Cancer, Genetics
- MeSH
- animals, humans, brassicaceae, brassica, vegetables, colorectal neoplasms, disease models, animal, glutathione transferase, risk factors, feeding behavior, genotype, polymorphism, genetic, gene-environment interaction, observational studies as topic
2 autores
- Genevieve Tse🇦🇺Nepean Hospital
- Guy D. Eslick🇦🇺The University of Sydney
Resumen
El texto original del estudio, en el idioma en que se publicó.
Evidence shows cruciferous vegetables exhibit chemoprotective properties, commonly attributed to their rich source of isothiocyanates. However, epidemiological data examining the association between cruciferous vegetable intake and colorectal neoplasms have been inconclusive. This meta-analysis examines the epidemiological evidence to characterize the association between cruciferous vegetable intake and risk of developing colorectal neoplasms. Thirty-three articles were included in the meta-analysis after a literature search of electronic databases. Subgroup analysis for individual cruciferae types (n = 8 studies) and GST polymorphism (n = 8 studies) were performed. Pooled adjusted odds ratios (ORs) comparing highest and lowest categories of dietary pattern scores were calculated. Results show a statistically significant inverse association between cruciferous vegetable intake and colon cancer [OR = 0.84; 95% confidence interval (CI): 0.72-0.98; P value heterogeneity < 0.001]. Broccoli in particular exhibited protective benefits against colorectal (CRC) neoplasms (OR = 0.80; 95% CI: 0.65-0.99; P value heterogeneity = 0.02). Stratification by GST genotype reveals that the GSTT1 null genotype confers a reduction in CRC risk (OR = 0.78; 95% CI: 0.64-0.95; P value heterogeneity = 0.32). This study provides support to the hypothesis that cruciferous vegetable intake protects against cancer of the colon. This study also demonstrates the significance of gene-diet interactions and the importance of assessing individual cruciferous vegetables.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.