Vitamin D during pregnancy and infancy and infant serum 25-hydroxyvitamin D concentration
Grant CC, Stewart AW, Scragg R, Milne T, Rowden J, Ekeroma A, Wall C, Mitchell EA, Crengle S, Trenholme A, Crane J, Camargo CA
Pediatrics · 127 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-12-17 · Pediatrics · vol. 133 · número 1 · págs. e143–e153
- Editorial
- American Academy of Pediatrics
- Citado
- 177 citas · más que el 99% de estudios similares · 11.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 49 trabajos
- Acceso
- De pago
- Áreas de investigación
- Vitamin D Research Studies · Vitamin K Research Studies · Neonatal Health and Biochemistry
- Palabras clave
- vitamin D supplementation, vitamin D3, 25-hydroxyvitamin D, pregnancy, infancy, maternal supplementation, umbilical cord blood, vitamin D dose, calcium
- MeSH
- humans, prenatal exposure delayed effects, vitamin d deficiency, cholecalciferol, vitamins, vitamin d, prenatal care, drug administration schedule, linear models, follow-up studies, double-blind method, pregnancy, dose-response relationship, drug, dietary supplements, adult, infant, female, male, prenatal nutritional physiological phenomena, medication adherence, intention to treat analysis, biomarkers
12 autores
- Cameron Charles Grant
- Alistair W. Stewart
- Robert K.R. Scragg
- Tania Milne
- Judy Rowden
- Alec Joseph Ekeroma
- Clare Rosemary Wall
- Edwin A. Mitchell
- Sue M. Crengle🇳🇿University of Auckland
- Adrian A. Trenholme🇳🇿Middlemore Hospital
- Julian Crane🇳🇿University of Otago
- Carlos A. Camargo🇺🇸Harvard University; Massachusetts General Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To determine the vitamin D dose necessary to achieve serum 25-hydroxyvitamin D (25(OH)D) concentration ≥ 20 ng/mL during infancy.
Methods
A randomized, double-blind, placebo-controlled trial in New Zealand. Pregnant mothers, from 27 weeks' gestation to birth, and then their infants, from birth to age 6 months, were randomly assigned to 1 of 3 mother/infant groups: placebo/placebo, vitamin D3 1000/400 IU, or vitamin D3 2000/800 IU. Serum 25(OH)D and calcium concentrations were measured at enrollment, 36 weeks' gestation, in cord blood, and in infants at 2, 4, and 6 months of age.
Results
Two-hundred-and-sixty pregnant women were randomized. At enrollment, the proportions with serum 25(OH)D ≥ 20 ng/mL for placebo, lower-dose, and higher-dose groups were 54%, 64%, and 55%, respectively. The proportion with 25(OH)D ≥ 20 ng/mL was larger in both intervention groups at 36 weeks' gestation (50%, 91%, 89%, P < .001). In comparison with placebo, the proportion of infants with 25(OH)D ≥ 20 ng/mL was larger in both intervention groups to age 4 months: cord blood (22%, 72%, 71%, P < .001), 2 months (50%, 82%, 92%, P < .001), and 4 months (66%, 87%, 87%, P = .004), but only in the higher-dose group at age 6 months (74%, 82%, 89%, P = .07; higher dose versus placebo P = .03, lower dose versus placebo P = .21).
Conclusions
Daily vitamin D supplementation during pregnancy and then infancy with 1000/400 IU or 2000/800 IU increases the proportion of infants with 25(OH)D ≥ 20 ng/mL, with the higher dose sustaining this increase for longer.
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