Walnut-enriched diet reduces fasting non-HDL-cholesterol and apolipoprotein B in healthy Caucasian subjects: a randomized controlled cross-over clinical trial
Wu L, Piotrowski K, Rau T, Waldmann E, Broedl UC, Demmelmair H, Koletzko B, Stark RG, Nagel JM, Mantzoros CS, Parhofer KG
Metabolism: clinical and experimental · 63 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
- Consumo medido con
- Comida provista por los investigadores
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-11-12 · Metabolism · vol. 63 · número 3 · págs. 382–391
- Editorial
- Elsevier BV
- Citado
- 89 citas · más que el 94% de estudios similares · 4.7× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 56 trabajos
- Acceso
- Acceso abierto (revista híbrida) · CC-BY-NC-ND
- Áreas de investigación
- Nuts composition and effects · Nutritional Studies and Diet · Fatty Acid Research and Health
- Palabras clave
- Juglans regia, non-HDL cholesterol, apolipoprotein B, lipid metabolism, coronary heart disease risk, postprandial lipemia, endothelial function, adipokines, inflammation, C-reactive protein, postmenopausal women, healthy older adults
- MeSH
- endothelium, humans, juglans, inflammation, insulin, glucose, triglycerides, chylomicrons, lipoproteins, vldl, c-reactive protein, apolipoproteins b, diet, fasting, prospective studies, cross-over studies, postprandial period, middle aged, female, male, lipid metabolism, cholesterol, ldl, cholesterol, hdl, cholesterol, vldl, adipokines, white people, glycated hemoglobin
11 autores
- WU Li-ya🇩🇪Ludwig-Maximilians-Universität München
- Katja Piotrowski🇩🇪Ludwig-Maximilians-Universität München
- Tiina Rau🇩🇪Ludwig-Maximilians-Universität München
- Elisa Waldmann🇩🇪Ludwig-Maximilians-Universität München
- Uli C. Broedl🇩🇪Ludwig-Maximilians-Universität München
- Hans Demmelmair🇩🇪Ludwig-Maximilians-Universität München
- Berthold Viktor Koletzko🇩🇪Ludwig-Maximilians-Universität München
- Renee G. Stark🇩🇪Helmholtz Munich
- Jutta Maria Nagel🇩🇪Ludwig-Maximilians-Universität München
- Christos Socrates Mantzoros🇺🇸Beth Israel Deaconess Medical Center
- Klaus Georg Parhofer🇩🇪 · autor de correspondenciaLudwig-Maximilians-Universität München
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background
Walnut consumption is associated with reduced risk of coronary heart disease (CHD).
Objective
We assessed the effect of walnuts on lipid and glucose metabolism, adipokines, inflammation and endothelial function in healthy Caucasian men and postmenopausal women ≥50years old.
Design
Forty subjects (mean±SEM: age 60±1years, BMI 24.9±0.6kg/m(2); 30 females) were included in a controlled, cross-over study and randomized to receive first a walnut-enriched (43g/d) and then a Western-type (control) diet or vice-versa, with each lasting 8weeks and separated by a 2-week wash-out. At the beginning and end of each diet phase, measurements of fasting values, a mixed meal test and an assessment of postprandial endothelial function (determination of microcirculation by peripheral artery tonometry) were conducted. Area under the curve (AUC), incremental AUC (iAUC) and treatment×time interaction (shape of the curve) were evaluated for postprandial triglycerides, VLDL-triglycerides, chylomicron-triglycerides, glucose and insulin.
Results
Compared with the control diet, the walnut diet significantly reduced non-HDL-cholesterol (walnut vs. control: -10±3 vs. -3±2mg/dL; p=0.025) and apolipoprotein-B (-5.0±1.3 vs. -0.2±1.1mg/dL; p=0.009) after adjusting for age, gender, BMI and diet sequence. Total cholesterol showed a trend toward reduction (p=0.073). Fasting VLDL-cholesterol, LDL-cholesterol, HDL-cholesterol, triglycerides and glucose, insulin, HOMA-IR, and HbA1c did not change significantly. Similarly, fasting adipokines, C-reactive protein, biomarkers of endothelial dysfunction, postprandial lipid and glucose metabolism and endothelial function were unaffected.
Conclusion
Daily consumption of 43g of walnuts for 8weeks significantly reduced non-HDL-cholesterol and apolipoprotein-B, which may explain in part the epidemiological observation that regular walnut consumption decreases CHD risk.
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