Financiado en parte por Danone
The chronic kidney disease Water Intake Trial (WIT): results from the pilot randomised controlled trial
Clark WF, Sontrop JM, Huang SH, Gallo K, Moist L, House AA, Weir MA, Garg AX
BMJ open · 31 citas
Etiquetas de revisión
Financiado por la industriaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (clasificado por nuestro filtro de IA)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiado por la industria
- Empresa
- Danone
Según 1 financiador declarado.
Publicación
- Publicado
- 2013-12-01 · BMJ Open · vol. 3 · número 12 · pág. e003666
- Editorial
- BMJ
- Citado
- 38 citas · más que el 92% de estudios similares · 3.3× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 31 trabajos
- Acceso
- Acceso abierto (revista) · CC-BY-NC
- Áreas de investigación
- Sodium Intake and Health · Chronic Kidney Disease and Diabetes · Dialysis and Renal Disease Management
- Palabras clave
- Medicine, Renal function, Urine, Albuminuria, Kidney disease, Randomized controlled trial, Creatinine, Internal medicine, Urology
8 autores
- William F. Clark🇨🇦 · autor de correspondenciaLondon Health Sciences Centre
- Jessica M. Sontrop🇨🇦Western University; London Health Sciences Centre
- Shih‐Han Susan Huang🇨🇦London Health Sciences Centre
- Kerri Gallo🇨🇦Western University
- Louise M. MOIST🇨🇦Western University; London Health Sciences Centre
- Andrew A. House🇨🇦London Health Sciences Centre
- Matthew A. Weir🇨🇦London Health Sciences Centre
- Amit X. Garg🇨🇦Western University; London Health Sciences Centre
Resumen
El texto original del estudio, en el idioma en que se publicó.
Background and objectives
Increased water intake may benefit kidney function. Prior to initiating a larger randomised controlled trial (RCT), we examined the safety and feasibility of asking adults with chronic kidney disease (CKD) to increase their water intake.
Design, setting, participants and measurements
Beginning in October 2012, we randomly assigned 29 adults with stage 3 CKD (estimated glomerular filtration rate (eGFR) 30-60 mL/min/1.73 m(2) and albuminuria) to one of the two groups of water intake: hydration (n=18) or standard (n=11). We asked the hydration group to increase their water intake by 1.0-1.5 L/day (in addition to usual intake, depending on sex and weight) for 6 weeks, while the control group carried on with their usual intake. Participants collected a 24 h urine sample at baseline and at 2 and 6 weeks after randomisation. Our primary outcome was the between-group difference in change in 24 h urine volume from baseline to 6 weeks.
Results
(63%)of participants were men, 81% were Caucasians and the average age was 61 years (SD 14 years). The average baseline eGFR was 40 mL/min/1.73 m(2) (SD 11 mL/min/1.73 m(2)); the median albumin to creatinine ratio was 19 mg/mmol (IQR 6-74 mg/mmol). Between baseline and 6-week follow-up, the hydration group's average 24 h urine volume increased by 0.7 L/day (from 2.3 to 3.0 L/day) and the control group's 24 h urine decreased by 0.3 L/day (from 2.0 to 1.7 L/day; between-group difference in change: 0.9 L/day (95% CI 0.4 to 1.5; p=0.002)). We found no significant changes in urine, serum osmolality or electrolyte concentrations, or eGFR. No serious adverse events or changes in quality of life were reported.
Conclusions
A pilot RCT indicates adults with stage 3 CKD can successfully and safely increase water intake by up to 0.7 L/day in addition to usual fluid intake. TRIAL REGISTRATION REGISTERED WITH CLINICAL TRIALSGOVERNMENT IDENTIFIER: NCT01753466.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial (CC BY-NC).
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