The effect of exogenous creatine phosphate on myocardial injury after percutaneous coronary intervention
Ke-Wu D, Xu-Bo S, Ying-Xin Z, Shi-Wei Y, Yu-Jie Z, Dong-Mei S, Yu-Yang L, De-An J, Zhe F, Zhi-Ming Z, Hai-Long G, Zhen-Xian Y, Chang-Sheng M
Angiology · 8 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-12-23 · Angiology · vol. 66 · número 2 · págs. 163–168
- Editorial
- SAGE Publishing
- Citado
- 14 citas · más que el 65% de estudios similares · 0.3× el promedio de su campo
- Referencias
- 28 trabajos
- Acceso
- De pago
- Áreas de investigación
- Coronary Interventions and Diagnostics · Acute Myocardial Infarction Research · Cardiac and Coronary Surgery Techniques
- Palabras clave
- phosphocreatine, myocardial injury, percutaneous coronary intervention, creatine kinase-MB, troponin I, intravenous infusion, cardioprotection
- MeSH
- humans, myocardial reperfusion injury, phosphocreatine, troponin i, treatment outcome, infusions, intravenous, drug administration schedule, up-regulation, cytoprotection, time factors, aged, middle aged, china, female, male, creatine kinase, mb form, percutaneous coronary intervention, biomarkers
13 autores
- Deng Ke-Wu🇨🇳Beijing Tongren Hospital; Capital Medical University; Beijing Anzhen Hospital
- Shi Xubo🇨🇳Beijing Tongren Hospital; Capital Medical University
- Yingxin Zhao🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Shiwei Yang🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Zhou Yujie🇨🇳 · autor de correspondenciaCapital Medical University; Beijing Anzhen Hospital
- Shi Dong-Mei🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Liu Yu-Yang🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Jia Dean🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Zhe Fang🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Zhou Zhi-Ming🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Hailong Ge🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Yan Zhenxian🇨🇳Capital Medical University; Beijing Anzhen Hospital
- Changsheng Ma🇨🇳Beijing Tongren Hospital; Capital Medical University; Beijing Anzhen Hospital
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
To evaluate the effect of exogenous creatine phosphate (CP) on myocardial injury after percutaneous coronary intervention (PCI).
Method
Four hundred patients were divided to receive conventional therapy (control group) or 3-day intravenous infusion of CP after PCI (CP group). Levels of creatine kinase MB (CK-MB) and troponin I (TnI) were measured before and on postprocedural day 3.
Results
Postprocedural CK-MB and TnI in the CP group were significantly increased compared to the control group. In the CP group, 8.0% and 5.0% of patients had an increase in CK-MB 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (19.0% and 9.0%, respectively); 12.0% and 10.0% of patients had an increase in TnI 1 to 3 times and >3 times, respectively, which were significantly lower than that of the control group (21.0% and 18.0%, respectively).
Conclusion
Exogenous CP was helpful to reduce myocardial injury after PCI.
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