Omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect in adults with metabolic syndrome
Tousoulis D, Plastiras A, Siasos G, Siasos G, Oikonomou E, Verveniotis A, Kokkou E, Maniatis K, Gouliopoulos N, Miliou A, Paraskevopoulos T, Stefanadis C
Atherosclerosis · 120 citas
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Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
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- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2013-10-25 · Atherosclerosis · vol. 232 · número 1 · págs. 10–16
- Editorial
- Elsevier BV
- Citado
- 168 citas · más que el 99% de estudios similares · 12.6× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 38 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Cardiovascular Health and Disease Prevention · Nitric Oxide and Endothelin Effects
- Palabras clave
- omega-3 polyunsaturated fatty acids, metabolic syndrome, endothelial function, arterial stiffness, anti-inflammatory activity, interleukin-6, plasminogen activator inhibitor-1, flow-mediated dilation, pulse wave velocity, fibrinolysis, triglycerides, cholesterol
- MeSH
- arteries, aorta, endothelium, vascular, humans, inflammation, blood glucose, lipids, fatty acids, omega-3, c-reactive protein, plasminogen activator inhibitor 1, anti-inflammatory agents, interleukin-6, body mass index, administration, oral, cross-over studies, double-blind method, fibrinolysis, adult, aged, middle aged, female, male, vascular stiffness, metabolic syndrome
11 autores
- Dimitris Tousoulis🇬🇷 · autor de correspondenciaNational and Kapodistrian University of Athens; Hippocration General Hospital
- Aris Plastiras🇬🇷National and Kapodistrian University of Athens
- Gerasimos Siasos🇬🇷National and Kapodistrian University of Athens; Hippocration General Hospital
- Evangelos K. Oikonomou🇬🇷National and Kapodistrian University of Athens
- Aleksis Verveniotis🇬🇷National and Kapodistrian University of Athens
- Eleni Kokkou🇬🇷National and Kapodistrian University of Athens
- Konstantinos Maniatis🇬🇷National and Kapodistrian University of Athens
- Nikolaos Gouliopoulos🇬🇷National and Kapodistrian University of Athens
- Antigoni Miliou🇬🇷National and Kapodistrian University of Athens
- Thodoris Paraskevopoulos🇬🇷National and Kapodistrian University of Athens
- Christodoulos Stefanadis🇬🇷National and Kapodistrian University of Athens
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objectives
Metabolic syndrome (MetS) is associated with adverse cardiovascular events, and impaired vascular function. In this study we evaluated the effects of omega-3 polyunsaturated fatty acids (PUFAs) supplementation on vascular function, inflammatory and fibrinolytic process in subjects with MetS.
Methods
We studied the effect of a 12 weeks oral treatment with 2 g/day of omega-3 PUFAs in 29 (15 male) subjects (mean age 44 ± 12 years) with MetS on three occasions (day0: baseline, day 28 and day 84). The study was carried out on two separate arms (PUFAs and placebo), according to a randomized, placebo-controlled, double-blind, cross-over design. The diagnosis of MetS was based on the guidelines of Adult Treatment Panel III definition. Endothelial function was evaluated by flow-mediated dilation (FMD) of the brachial artery. Carotid-femoral pulse wave velocity (PWV) was measured as an index of aortic stiffness. Serum levels of interleukin-6(IL-6) and plasminogen activator inhibitor-1(PAI-1) were measured by ELISA.
Results
Treatment with PUFAs resulted in a significant improvement from day 0 to 28 and 84 in FMD and PWV (p < 0.001 for all). Nevertheless, treatment with placebo resulted in no significant changes in FMD (p = 0.63) and PWV (p = 0.17). Moreover, PUFAs treatment, compared to placebo, decreased IL-6 levels (p = 0.03) and increased PAI-1 levels (p = 0.03). Finally, treatment with PUFAs resulted in a significant decrease in fasting triglyceride levels from day 0 to 28 and 84 (p < 0.001) and in serum total cholesterol levels (p < 0.001).
Conclusions
In subjects with MetS, treatment with omega-3 PUFAs improved endothelial function and arterial stiffness with a parallel antiinflammatory effect.
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