Efficacy of vitamin D supplementation in depression in adults: a systematic review
Li G, Mbuagbaw L, Samaan Z, Falavigna M, Zhang S, Adachi JD, Cheng J, Papaioannou A, Thabane L
The Journal of clinical endocrinology and metabolism · 99 citas
Cómo se estudió
- Diseño
- Metaanálisis (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación independiente
- Gobierno
- Canadian Institutes of Health Research
- Gobierno
- CIHR
- Subvenciones
- Canadian Institutes of Health Research (88225_1)
Según 2 financiadores declarados.
Publicación
- Publicado
- 2013-12-12 · J Clin Endocrinol Metab · vol. 99 · número 3 · págs. 757–767
- Editorial
- Oxford University Press
- Citado
- 143 citas · más que el 82% de estudios similares · 1.7× el promedio de su campo
- Referencias
- 61 trabajos
- Acceso
- Acceso abierto (copia en repositorio)
- Áreas de investigación
- Vitamin D Research Studies · Treatment of Major Depression · Nutrition and Health Studies
- Palabras clave
- vitamin D supplementation, depression, vitamin D deficiency, depressive symptoms, adults, placebo comparison, quality of evidence
- MeSH
- humans, vitamin d, treatment outcome, depression, depressive disorder, quality of life, dietary supplements, adult
9 autores
- Guowei Li
- Lawrence C. E. Mbuagbaw
- Zainab Samaan
- Maicon Falavigna🇧🇷Universidade Federal do Rio Grande do Sul
- Shiyuan Zhang
- Jonathan Derrick Adachi🇨🇦McMaster University
- Ji Cheng🇨🇦McMaster University
- Αλεξάνδρα Παπαϊωάννου🇨🇦McMaster University
- Lehana Thabane🇨🇦 · autor de correspondenciaMcMaster University
Resumen
El texto original del estudio, en el idioma en que se publicó.
Context
Randomized controlled trials (RCTs) investigating the efficacy of vitamin D (Vit D) in depression provided inconsistent results.
Objective
We aim to summarize the evidence of RCTs to assess the efficacy of oral Vit D supplementation in depression compared to placebo.
Data sources
We searched electronic databases, two conference proceedings, and gray literature by contacting authors of included studies.
Study selection
We selected parallel RCTs investigating the effect of oral Vit D supplementation compared with placebo on depression in adults at risk of depression, with depression symptoms or a primary diagnosis of depression.
Data extraction
Two reviewers independently extracted data from relevant literature.
Data synthesis
Classical and Bayesian random-effects meta-analyses were used to pool relative risk, odds ratio, and standardized mean difference. The quality of evidence was assessed using the Grading of Recommendations Assessment, Development and Evaluation tool.
Results
Six RCTs were identified with 1203 participants (72% females) including 71 depressed patients; five of the studies involved adults at risk of depression, and one trial used depressed patients. Results of the classical meta-analysis showed no significant effect of Vit D supplementation on postintervention depression scores (standardized mean difference = -0.14, 95% confidence interval = -0.41 to 0.13, P = .32; odds ratio = 0.93, 95% confidence interval = 0.54 to 1.59, P = .79). The quality of evidence was low. No significant differences were demonstrated in subgroup or sensitivity analyses. Similar results were found when Bayesian meta-analyses were applied.
Conclusions
There is insufficient evidence to support the efficacy of Vit D supplementation in depression symptoms, and more RCTs using depressed patients are warranted.
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