Omega-3 supplementation improves cognition and modifies brain activation in young adults
Bauer I, Hughes M, Rowsell R, Cockerell R, Pipingas A, Crewther S, Crewther D
Human psychopharmacology · 76 citas
Etiquetas de revisión
Financiación no declaradaDatos neutrales que nuestra revisión registró sobre cómo se hizo este estudio. Describen el método, nunca si nos gusta el resultado.
Cómo se estudió
- Diseño
- Ensayo controlado aleatorizado (indexado por PubMed)
- Estudiado en
- Personas
- Resultado principal
- Marcadores de salud y funcionamiento
Quién lo pagó
- Financiación
- Financiación no declarada
Publicación
- Publicado
- 2014-01-28 · Hum Psychopharmacol · vol. 29 · número 2 · págs. 133–144
- Editorial
- Wiley
- Citado
- 102 citas · más que el 98% de estudios similares · 8.9× el promedio de su campo
- Impacto
- Entre el 10 % más citado de su campo
- Referencias
- 44 trabajos
- Acceso
- De pago
- Áreas de investigación
- Fatty Acid Research and Health · Neural and Behavioral Psychology Studies · Dementia and Cognitive Impairment Research
- Palabras clave
- omega-3 supplementation, eicosapentaenoic acid, docosahexaenoic acid, cognitive performance, brain activation, Stroop task, spatial working memory, anterior cingulate cortex, precentral gyrus, young adults
- MeSH
- brain, humans, fatty acids, omega-3, docosahexaenoic acids, eicosapentaenoic acid, arachidonic acid, magnetic resonance imaging, brain mapping, cross-over studies, double-blind method, cognition, memory, short-term, space perception, reaction time, neuropsychological tests, dietary supplements, adult, female, male, young adult, stroop test
7 autores
- Isabelle E. Bauer🇦🇺Swinburne University of Technology
- Matthew Edward Hughes🇦🇺Swinburne University of Technology
- Renee Rowsell🇦🇺Swinburne University of Technology
- Robyn Cockerell🇦🇺Swinburne University of Technology
- Andrew Pipingas🇦🇺Swinburne University of Technology
- Sheila G. Crewther🇦🇺La Trobe University
- David P. Crewther🇦🇺 · autor de correspondenciaSwinburne University of Technology
Resumen
El texto original del estudio, en el idioma en que se publicó.
Objective
The current study aimed to investigate the effects of eicosapentaenoic acid (EPA)-rich and docosahexaenoic acid (DHA)-rich supplementations on cognitive performance and functional brain activation.
Design
A double-blind, counterbalanced, crossover design, with a 30-day washout period between two supplementation periods (EPA-rich and DHA-rich) was employed. Functional magnetic resonance imaging scans were obtained during performance of Stroop and Spatial Working Memory tasks prior to supplementation and after each 30-day supplementation period.
Results
Both supplementations resulted in reduced ratio of arachidonic acid to EPA levels. Following the EPA-rich supplementation, there was a reduction in functional activation in the left anterior cingulate cortex and an increase in activation in the right precentral gyrus coupled with a reduction in reaction times on the colour-word Stroop task. By contrast, the DHA-rich supplementation led to a significant increase in functional activation in the right precentral gyrus during the Stroop and Spatial Working Memory tasks, but there was no change in behavioural performance.
Conclusions
By extending the theory of neural efficiency to the within-subject neurocognitive effects of supplementation, we concluded that following the EPA-rich supplementation, participants' brains worked 'less hard' and achieved a better cognitive performance than prior to supplementation. Conversely, the increase in functional activation and lack of improvement in time or accuracy of cognitive performance following DHA-rich supplementation may indicate that DHA-rich supplementation is less effective than EPA-rich supplementation in enhancing neurocognitive functioning after a 30-day supplementation period in the same group of individuals.
Resumen vía Europe PMC. Los derechos de autor siguen siendo de los autores o la editorial.
Confianza de la comunidad
Cargando…
¿Cuánto confías en los hallazgos de este estudio?
Comentarios
¿Algo está mal aquí?
Señala este estudio si su información, etiquetas o financiación parecen incorrectas. Un editor revisa cada señalamiento.
Información educativa sobre investigación publicada. No es consejo médico ni una recomendación para empezar o dejar nada.